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Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite  |  View/Download:5/0  |  Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:13/0  |  Submit date:2019/01/17
Lsd1  Demethylase  Histone  Breast Cancer  Prostate Cancer  Acute Myeloid Leukemia  Cancer Therapy  
A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells Journal article
JOURNAL OF MEDICINAL CHEMISTRY, 2017,Volume: 60,Issue: 6,Page: 2597-2603
Authors:  Yang, Chao;  Wang, Wanhe;  Liang, Jia-Xin;  Li, Guodong;  Vellaisamy, Kasipandi;  Wong, Chun-Yuen;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:17/0  |  Submit date:2018/10/30
JMJD-1.2/PHF8 controls axon guidance by regulating hedgehoglike signaling Journal article
Development (Cambridge), 2017,Volume: 144,Issue: 5,Page: 856-865
Authors:  Riveiro A.R.;  Mariani L.;  Malmberg E.;  Amendola P.G.;  Peltonen J.;  Wong G.;  Salcini A.E.
Favorite  |  View/Download:22/0  |  Submit date:2018/12/18
Axon guidance  C. elegans  Epigenetics  Hedgehog signaling  Histone demethylase  Neuronal development  
Impaired removal of H3K4 methylation affects cell fate determination and gene transcription Journal article
Development (Cambridge), 2016,Volume: 143,Issue: 20,Page: 3751-3762
Authors:  Lussi Y.C.;  Mariani L.;  Friis C.;  Peltonen J.;  Myers T.R.;  Krag C.;  Wong G.;  Salcini A.E.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
C. Elegans  Enhancer  Gene Transcription  H3k4 Methylation  Kdm5  Rbr-2  Vpc Differentiation  
Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages Journal article
Cellular Signalling, 2014,Volume: 26,Issue: 9,Page: 1783-1791
Authors:  Yan Q.;  Sun L.;  Zhu Z.;  Wang L.;  Li S.;  Ye R.D.
Favorite  |  View/Download:0/0  |  Submit date:2018/11/07
Histone demethylase  Jmjd3  Macrophages  Serum amyloid A  Sterile inflammation  
Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms Journal article
Phytomedicine, 2012,Volume: 19,Issue: 6,Page: 535-544
Authors:  Or P.M.Y.;  Lam F.F.Y.;  Kwan Y.W.;  Cho C.H.;  Lau C.P.;  Yu H.;  Lin G.;  Lau C.B.S.;  Fung K.P.;  Leung P.C.;  Yeung J.H.K.
Favorite  |  View/Download:7/0  |  Submit date:2019/01/17
Cyp1a2  Cyp2c9  Cyp2d6  Cyp2e1  Cyp3a4  Human Liver Microsomes  Radix Astragali  Radix Rehmanniae  
Jarid2 and PRC2, partners in regulating gene expression Journal article
GENES & DEVELOPMENT, 2010,Volume: 24,Issue: 4,Page: 368-380
Authors:  Gang Li;  Raphael Margueron;  Manching Ku;  Pierre Chambon;  Bradley E. Bernstein;  Danny Reinberg
Favorite  |  View/Download:4/0  |  Submit date:2019/01/22
Polycomb  Chromatin  Histone Methylation  Jarid2