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Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
Favorite | View/Download:231/0 | TC[WOS]:4 TC[Scopus]:10 | Submit date:2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
Favorite | View/Download:39/0 | TC[WOS]:5 TC[Scopus]:9 | Submit date:2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:533/13 | TC[WOS]:7 TC[Scopus]:13 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier Journal article
PHARMACOLOGICAL RESEARCH, 2017,Volume: 125,Page: 246-257
Authors:  Li, Ye;  Chen, Tongkai;  Miao, Xiaoqing;  Yi, Xiang;  Wang, Xueqing;  Zhao, Haitao;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite | View/Download:39/0 | TC[WOS]:12 TC[Scopus]:20 | Submit date:2018/10/30
Blood Brain Barrier (Bbb)  Zebrafish  Fluorescence Dyes  Natural Products  Drug Delivery Systems  Permeability  
Pluronic P85/F68 Micelles of Baicalein Could Interfere with Mitochondria to Overcome MRP2-Mediated Efflux and Offer Improved Anti-Parkinsonian Activity Journal article
Molecular Pharmaceutics, 2017,Volume: 14,Issue: 10,Page: 3331-3342
Authors:  Tongkai Chen;  Ye Li;  Chuwen Li;  Xiang Yi;  Ruibing Wang;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:21/0 | TC[WOS]:8 TC[Scopus]:14 | Submit date:2018/11/06
Baicalein  Fluorescence Resonance Energy Transfer (Fret)  Micelles  Mitochondria  Multidrug Resistance-associated Protein 2 (Mrp2)  Neuroprotective Effect  
Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers Journal article
Colloids and Surfaces B: Biointerfaces, 2017,Volume: 156,Page: 227-235
Authors:  Li Y.;  Miao X.;  Chen T.;  Yi X.;  Wang R.;  Zhao H.;  Lee S.M.-Y.;  Wang X.;  Zheng Y.
Favorite | View/Download:18/0 | TC[WOS]:16 TC[Scopus]:20 | Submit date:2018/11/06
Biological Barriers  Nanocrystals  Transport  Zebrafish  
Small-Sized mPEG PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity Journal article
ACS APPLIED MATERIALS & INTERFACES, 2017,Volume: 9,Issue: 11,Page: 9516-9527
Authors:  Chen, Tongkai;  Li, Chuwen;  Li, Ye;  Yi, Xiang;  Wang, Ruibing;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite | View/Download:78/0 | TC[WOS]:21 TC[Scopus]:34 | Submit date:2018/10/30
Brain Delivery  Cellular Uptake  Fluorescence Resonance Energy Transfer (Fret)  Mpeg-plga Nanoparticles  Oral Bioavailability  Schisantherin a  
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Zaijun Zhang;  Gaoxiao Zhang;  Yewei Sun;  Samuel S. W. Szeto;  Henry C. H. Law;  Quan Quan;  Guohui Li;  Pei Yu;  Eiketsu Sho;  Michael K. W. Siu;  Simon M. Y. Lee;  Ivan K. Chu;  Yuqiang Wang
Favorite | View/Download:18/0 | TC[WOS]:11 TC[Scopus]:22 | Submit date:2018/11/06
A microfluidic linear node array for the study of protein-ligand interactions Journal article
Lab on a Chip, 2014,Volume: 14,Issue: 20,Page: 3993-3999
Authors:  Li C.-W.;  Yu G.;  Jiang J.;  Lee S.M.-Y.;  Yi C.;  Yue W.;  Yang M.
Favorite | View/Download:15/0 | TC[WOS]:1 TC[Scopus]:1 | Submit date:2018/11/06
Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase Journal article
PLoS ONE, 2012,Volume: 7,Issue: 9
Authors:  Cui W.;  Zhang Z.;  Li W.;  Mak S.;  Hu S.;  Zhang H.;  Yuan S.;  Rong J.;  Choi T.C.;  Lee S.M.Y.;  Han Y.
Favorite | View/Download:10/0 | TC[WOS]:18 TC[Scopus]:21 | Submit date:2018/11/06