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Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
STEM CELL REPORTS, 2019,Volume: 13,Issue: 2,Page: 338-351
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng;  Yiqi Yang;  Shreyas Lingadahalli;  Edwin Cheung;  Gang Li;  Weiwei Liu;  Jianbo Wan;  Yang Zhao;  Guokai Chen
Favorite | View/Download:23/0 | TC[WOS]:1 TC[Scopus]:3 | Submit date:2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation  
Discovery and preliminary SAR of 14-aryloxy-andrographolide derivatives as antibacterial agents with immunosuppressant activity Journal article
RSC ADVANCES, 2018,Volume: 8,Issue: 17,Page: 9440-9456
Authors:  Li, Feng;  Li, Xiao-Min;  Sheng, Dekuan;  Chen, Shao-Ru;  Nie, Xin;  Liu, Zhuyun;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Wang, Ying;  Zhou, Guo-Chun
View | Adobe PDF | Favorite | View/Download:539/15 | TC[WOS]:5 TC[Scopus]:7 | Submit date:2018/10/30
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite | View/Download:14/0 | TC[WOS]:3 TC[Scopus]:3 | Submit date:2018/12/18
Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material Journal article
BIOMATERIALS, 2017,Volume: 139,Page: 39-55
Authors:  Niu, Yiming;  Li, Qiu;  Xie, Ruiyu;  Liu, Shang;  Wang, Ruibing;  Xing, Panfei;  Shi, Yuchen;  Wang, Yitao;  Dong, Lei;  Wang, Chunming
View | Adobe PDF | Favorite | View/Download:517/16 | TC[WOS]:21 TC[Scopus]:26 | Submit date:2018/10/30
Bioactive Coating  Glucomannan Polysaccharides  Scaffold-tissue Integration  Macrophages  Osteogenesis  
Smad4 is required to inhibit osteoclastogenesis and maintain bone mass Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Morita M.;  Yoshida S.;  Iwasaki R.;  Yasui T.;  Sato Y.;  Kobayashi T.;  Watanabe R.;  Oike T.;  Miyamoto K.;  Takami M.;  Ozato K.;  Deng C.-X.;  Aburatani H.;  Tanaka S.;  Yoshimura A.;  Toyama Y.;  Matsumoto M.;  Nakamura M.;  Kawana H.;  Nakagawa T.;  Miyamoto T.
Favorite | View/Download:12/0 | TC[WOS]:7 TC[Scopus]:8 | Submit date:2018/12/13
The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100 Journal article
Science Signaling, 2016,Volume: 9,Issue: 447
Authors:  Fusco A.J.;  Mazumder A.;  Wang V.Y.-F.;  Tao Z.;  Ware C.;  Ghosh G.
Favorite | View/Download:12/0 | TC[WOS]:7 TC[Scopus]:7 | Submit date:2019/01/15
Research and development of antibiotics: insights from patents and citation network Journal article
EXPERT OPINION ON THERAPEUTIC PATENTS, 2016,Volume: 26,Issue: 5,Page: 617-627
Authors:  Zhang, M;  Kong, XJ;  Zheng, J;  Wan, JB;  Wang, YT;  Hu, YJ;  Shao, R
Favorite | View/Download:18/0 | TC[WOS]:2 TC[Scopus]:3 | Submit date:2019/01/19
Antibiotics  Patent  Patent Citation Network  Technology Flows  Technology Landscape  
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite | View/Download:15/0 | TC[WOS]:57 TC[Scopus]:68 | Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
Evaluation of radiation dose and image quality of CT scan for whole-body pediatric PET/CT: A phantom study Journal article
Medical Physics, 2014,Volume: 41,Issue: 9
Authors:  Yang C.-C.;  Liu S.-H.;  Mok G.S.P.;  Wu T.-H.
Favorite | View/Download:17/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/12/18
Image Quality  Pediatric Patients  Radiation Dose  Whole-body Pet/ct  
APC/C is an essential regulator of centrosome clustering Journal article
Nature Communications, 2014,Volume: 5
Authors:  Konstantinos Drosopoulos;  Chan Tang;  William C. H. Chao;  Spiros Linardopoulos
Favorite | View/Download:13/0 | TC[WOS]:28 TC[Scopus]:35 | Submit date:2018/12/18