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Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 7,Page: 3562-3568
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/18
Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation Journal article
RSC Advances, 2016,Volume: 6,Issue: 82,Page: 78762-78767
Authors:  Zhang S.-L.;  Zhang W.;  Xiao Q.;  Yang Z.;  Hu X.;  Wei Z.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
Discovery of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl) cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity Journal article
Journal of Medicinal Chemistry, 2013,Volume: 56,Issue: 5,Page: 2125-2138
Authors:  Foote K.M.;  Blades K.;  Cronin A.;  Fillery S.;  Guichard S.S.;  Hassall L.;  Hickson I.;  Jacq X.;  Jewsbury P.J.;  McGuire T.M.;  Nissink J.W.M.;  Odedra R.;  Page K.;  Perkins P.;  Suleman A.;  Tam K.;  Thommes P.;  Broadhurst R.;  Wood C.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18