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Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:119/4  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Wang, Shengpeng;  Wang, Anqi;  Shao, Min;  Lin, Ligen;  Li, Peng;  Wang, Yitao
View  |  Adobe PDF(3646Kb)  |  Favorite  |  View/Download:106/4  |  Submit date:2018/10/30
Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor beta-independent mechanism Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Li, Ao;  Zhang, Jingyao;  Zhang, Xiaoxun;  Wang, Jun;  Wang, Songsong;  Xiao, Xiao;  Wang, Rui;  Li, Peng;  Wang, Yitao
View  |  Adobe PDF(3646Kb)  |  Favorite  |  View/Download:115/1  |  Submit date:2018/10/30
Big data analysis of global advances in pharmaceutics and drug delivery 1980-2014 Journal article
DRUG DISCOVERY TODAY, 2017,Volume: 22,Issue: 8,Page: 1201-1208
Authors:  Zhang, Weixiang;  Zhao, Qianqian;  Deng, Junling;  Hu, Yuanjia;  Wang, Yitao;  Ouyang, Defang
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Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Wang, Yitao;  Zhang, Chunxue;  Jin, Yuelei;  Wang, Sen;  He, Qing;  Liu, Zhu;  Ai, Qing;  Lei, Yunlong;  Li, Yi;  Song, Fangzhou;  Bu, Youquan
Favorite  |  View/Download:2/0  |  Submit date:2018/11/01
Anticancer osmium complex inhibitors of the HIF-1 alpha and p300 protein-protein interaction Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Yang, Chao;  Wang, Wanhe;  Li, Guo-Dong;  Zhong, Hai-Jing;  Dong, Zhen-Zhen;  Wong, Chun-Yuen;  Kwong, Daniel W. J.;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:7/0  |  Submit date:2018/10/30
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 7,Page: 3562-3568
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/18
Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation Journal article
RSC Advances, 2016,Volume: 6,Issue: 82,Page: 78762-78767
Authors:  Zhang S.-L.;  Zhang W.;  Xiao Q.;  Yang Z.;  Hu X.;  Wei Z.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Alteration of electrostatic surface potential enhances affinity and tumor killing properties of anti-ganglioside GD2monoclonal antibody hu3F8 Journal article
Journal of Biological Chemistry, 2015,Volume: 290,Issue: 21,Page: 13017-13027
Authors:  Zhao Q.;  Ahmed M.;  Guo H.-F.;  Cheung I.Y.;  Cheung N.-K.V.
Favorite  |  View/Download:4/0  |  Submit date:2019/01/16
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex