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Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
Favorite  |  View/Download:217/0  |  Submit date:2020/01/16
Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
Sodium Tanshinone Iia Sulfonate  Salvia Miltiorrhiza  Hemorrhagic Stroke  Atorvastatin  Rock  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:285/7  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier Journal article
PHARMACOLOGICAL RESEARCH, 2017,Volume: 125,Page: 246-257
Authors:  Li, Ye;  Chen, Tongkai;  Miao, Xiaoqing;  Yi, Xiang;  Wang, Xueqing;  Zhao, Haitao;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite  |  View/Download:20/0  |  Submit date:2018/10/30
Blood Brain Barrier (Bbb)  Zebrafish  Fluorescence Dyes  Natural Products  Drug Delivery Systems  Permeability  
Zebrafish as a visual and dynamic model to study the transport of nanosized drug delivery systems across the biological barriers Journal article
Colloids and Surfaces B: Biointerfaces, 2017,Volume: 156,Page: 227-235
Authors:  Li Y.;  Miao X.;  Chen T.;  Yi X.;  Wang R.;  Zhao H.;  Lee S.M.-Y.;  Wang X.;  Zheng Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/11/06
Biological Barriers  Nanocrystals  Transport  Zebrafish  
Small-Sized mPEG PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity Journal article
ACS APPLIED MATERIALS & INTERFACES, 2017,Volume: 9,Issue: 11,Page: 9516-9527
Authors:  Chen, Tongkai;  Li, Chuwen;  Li, Ye;  Yi, Xiang;  Wang, Ruibing;  Lee, Simon Ming-Yuen;  Zheng, Ying
Favorite  |  View/Download:22/0  |  Submit date:2018/10/30
Brain Delivery  Cellular Uptake  Fluorescence Resonance Energy Transfer (Fret)  Mpeg-plga Nanoparticles  Oral Bioavailability  Schisantherin a  
A microfluidic linear node array for the study of protein-ligand interactions Journal article
Lab on a Chip, 2014,Volume: 14,Issue: 20,Page: 3993-3999
Authors:  Li C.-W.;  Yu G.;  Jiang J.;  Lee S.M.-Y.;  Yi C.;  Yue W.;  Yang M.
Favorite  |  View/Download:7/0  |  Submit date:2018/11/06
Unexpected Neuronal Protection of SU5416 against 1-Methyl-4-Phenylpyridinium Ion-Induced Toxicity via Inhibiting Neuronal Nitric Oxide Synthase Journal article
PLoS ONE, 2012,Volume: 7,Issue: 9
Authors:  Cui W.;  Zhang Z.;  Li W.;  Mak S.;  Hu S.;  Zhang H.;  Yuan S.;  Rong J.;  Choi T.C.;  Lee S.M.Y.;  Han Y.
Favorite  |  View/Download:5/0  |  Submit date:2018/11/06
Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish Journal article
International Journal of Molecular Medicine, 2011,Volume: 27,Issue: 2,Page: 195
Authors:  Zhang Z.J.;  Cheang L.C.V.;  Wang M.W.;  Lee S.M.-Y.
Favorite  |  View/Download:4/0  |  Submit date:2018/10/30
Neuroprotection  Parkinson's Disease  Quercetin  Zebrafish