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Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors Journal article
DRUG DISCOVERY TODAY, 2018,Volume: 23,Issue: 7,Page: 1407-1415
Authors:  Zhang, Shao-Lin;  He, Yun;  Tam, Kin Yip
Favorite  |  View/Download:8/0  |  Submit date:2018/10/30
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 2,Page: 204-216
Authors:  Yang, Zheng;  Tam, Kin Yip
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
Combination  Egfr-tki  Nsclc  Chemotherapy  Targeted Therapy  Immunotherapy  
Cytoskeleton Molecular Motors: Structures and Their Functions in Neuron Journal article
International Journal of Biological Sciences, 2016,Volume: 12,Issue: 9,Page: 1083-1092
Authors:  Qingpin Xiao;  Xiaohui Hu;  Zhiyi Wei;  Kin Yip Tam
Favorite  |  View/Download:0/0  |  Submit date:2019/01/07
Cytoskeleton Motors  Myosin  Kinesin  Cytoplasmic Dynein  Neuron  
Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents Journal article
Drug Discovery Today, 2015,Volume: 20,Issue: 9,Page: 1112-1119
Authors:  Shao-Lin Zhang;  Xiaohui Hu;  Wen Zhang;  Huankai Yao;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Animal models for Alzheimer’sdisease: a focused review of transgenic rodent models and behavioral assessment methods Journal article
ADMET & DMPK, 2015,Volume: 3,Issue: 3,Page: 242-253
Authors:  Xiaoli Wu;  Jing Li;  Wei Zhou;  Kin Tam
Favorite  |  View/Download:0/0  |  Submit date:2019/01/07
Neurodegeneration  Transgenic Mice  Behavioural Alteration  Morris Water Maze  Radial Arm Water Maze  Cognitive Impairmen  
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
Chemical and Physical Approaches for the Treatment of Alzheimer's Disease Journal article
ADMET & DMPK, 2015,Volume: 3,Issue: 3,Page: 216-234
Authors:  Jing Li;  WeiZhou;  Xiaoli Wu;  KinTam
Favorite  |  View/Download:0/0  |  Submit date:2019/01/07
Alzheimer’s Disease  Β-amyloid Peptide  Tau Protein  Pharmacological Strategies  Deep Brain Stimulation  Neurobiological Pathogenesis  
Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs Journal article
ADMET & DMPK, 2014,Volume: 2,Issue: 3,Page: 143-156
Authors:  Matěj Velický;  Andrew N.J. Rodgers;  Robert A.W. Dryfe;  Kin Tam
Favorite  |  View/Download:4/0  |  Submit date:2019/01/07
Cyclic Voltammetry  Partition Coefficient  Diffusion Coefficient  Permeability  Ities  
The roles of doxorubicin in hepatocellular carcinoma Journal article
ADMET & DMPK, 2013,Volume: 1,Issue: 3,Page: 29-44
Authors:  Kin Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Primary Liver Cancer  Anticancer  Cytotoxic Drug  Transarterial Chemoembolization  Drug Eluting Beads  
Estimating the “First in human” dose – a revisit with particular emphasis on oncology drugs Journal article
ADMET & DMPK, 2013,Volume: 1,Issue: 4,Page: 63-75
Authors:  Kin Tam
Favorite  |  View/Download:6/0  |  Submit date:2019/01/07
Initial Dose  Starting Dose  Clinical Trial  Noael  Mabel  Cytotoxic  Anticancer  Combination Therapy Study