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Oral delivery of a nanocrystal formulation of schisantherin a with improved bioavailability and brain delivery for the treatment of Parkinson's disease Journal article
Molecular Pharmaceutics, 2016,Volume: 13,Issue: 11,Page: 3864-3875
Authors:  Tongkai Chen;  Chuwen Li;  Ye Li;  Xiang Yi;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:10/0 | TC[WOS]:18 TC[Scopus]:0 | Submit date:2018/11/06
Brain Delivery  Dissolution  Nanocrystals  Oral Bioavailability  Parkinson's Disease (Pd)  
A New Danshensu Derivative Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in Vitro and in Vivo Journal article
American Journal of Chinese Medicine, 2016,Volume: 44,Issue: 7,Page: 1349-1361
Authors:  Guozhen Cui;  Luchen Shan;  Yang Chen;  Hefeng Zhou;  Yuqiang Wang;  Simon Ming-Yuen Lee
Favorite | View/Download:9/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/11/06
Anti-inflammation  Anti-oxidation  Danshensu Derivative  Neuroprotection  
Discovery, synthesis, and functional characterization of a novel neuroprotective natural product from the fruit of alpinia oxyphylla for use in Parkinson's disease through LC/MS-based multivariate data analysis-guided fractionation Journal article
Journal of Proteome Research, 2016,Volume: 15,Issue: 8,Page: 2595-2606
Authors:  Guohui Li;  Zaijun Zhang;  Quan Quan;  Renwang Jiang;  Samuel S.W. Szeto;  Shuai Yuan;  Wing-tak Wong;  Herman H. C. Lam;  Simon Ming-Yuen Lee;  Ivan K. Chu
Favorite | View/Download:11/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/11/06
Natural Products  Neuroprotective  Nrf2  Parkinson's Disease  Proteomics  
Protective effects of Otophylloside N on Pentylenetetrazol-induced neuronal injury in vitro and in vivo Journal article
Frontiers in Pharmacology, 2016,Volume: 7,Issue: JUL
Authors:  Sheng F.;  Chen M.;  Tan Y.;  Xiang C.;  Zhang M.;  Li B.;  Su H.;  He C.;  Wan J.;  Li P.
Favorite | View/Download:13/0 | TC[WOS]:5 TC[Scopus]:0 | Submit date:2018/12/28
Cynanchum Otophyllum Schneid  Epilepsy  Neuroprotective Effect, Apoptosis  Otophylloside n  Pentylenetetrazol  
Transport Mechanism of Coumarin 6 Nanocrystals with Two Particle Sizes in MDCKII Monolayer and Larval Zebrafish Journal article
ACS Applied Materials and Interfaces, 2016,Volume: 8,Issue: 20,Page: 12620-12630
Authors:  Xiaoqing Miao;  Ye Li;  Xueqing Wang;  Simon Ming-Yuen Lee;  Ying Zheng
Favorite | View/Download:8/0 | TC[WOS]:24 TC[Scopus]:0 | Submit date:2018/11/06
Epithelial Cells  Nanocrystals  Particle Size  Transport Mechanism  Zebrafish  
Zebrafish: An in-vivo model to evaluate absorption and biodistribution of nanocrystals Journal article
Nanomedicine: Nanotechnology, Biology, and Medicine, 2016,Volume: 12,Issue: 2,Page: 573
Authors:  Ye Li;  Xiaoqing Miao;  Liang Wang;  Xiang Yi;  Simon M.Y. Lee;  Ying Zheng
Favorite | View/Download:8/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/04/08
A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish Journal article
Chemical Communications, 2016,Volume: 52,Issue: 24,Page: 4450
Authors:  Zhifeng Mao;  Modi Wang;  Jinbiao Liu;  Li-Juan Liu;  Simon Ming-Yuen Lee;  Chung-Hang Leung;  Dik-Lung Ma
Favorite | View/Download:12/0 | TC[WOS]:60 TC[Scopus]:0 | Submit date:2018/10/30
The transcriptome of the zoanthid protopalythoa variabilis (cnidaria, anthozoa) predicts a basal repertoire of toxin-like and venom-Auxiliary polypeptides Journal article
Genome Biology and Evolution, 2016,Volume: 8,Issue: 9,Page: 3045-3064
Authors:  Chen Huang;  Jean-Étienne RL Morlighem;  Hefeng Zhou;  Érica P Lima;  Paula B Gomes;  Jing Cai;  Inchio Lou;  Carlos D Pérez;  Simon Ming Lee;  Gandhi Rádis-Baptista
Favorite | View/Download:8/0 | TC[WOS]:19 TC[Scopus]:0 | Submit date:2018/11/06
Hexacorallia  Molecular Toxinology  Peptide Toxin  Rna-seq  Transcriptome  Venomics  Zoanthidea  
Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs Journal article
European Journal of Pharmacology, 2016,Volume: 789,Page: 344-353
Authors:  JingjingLia;  YuranPeng;  Shang Li;  Yicheng Sun;  Judy Yuet-Wa Chan;  Guozhen Cui;  Decai Wang;  Guo-Chun Zhou;  Simon Ming-Yuen Lee
Favorite | View/Download:9/0 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/11/06
Andrographolide  Angiogenesis  Zebrafish  
Differential: In vitro and in vivo anti-angiogenic activities of acetal and ketal andrographolide derivatives in HUVEC and zebrafish models Journal article
RSC Advances, 2016,Volume: 6,Issue: 105,Page: 102831-102842
Authors:  Dekuan Sheng;  Jingjing Li;  Kun Wang;  Yuran Peng;  Shang Li;  Yicheng Sun;  Zhuyun Liu;  Decai Wang;  Simon Ming Yuen Lee;  Guo-Chun Zhou
Favorite | View/Download:12/0 | TC[WOS]:5 TC[Scopus]:0 | Submit date:2018/11/06