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A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
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Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF  
A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Hu, Shengquan;  Hu, Huihui;  Mak, Shinghung;  Cui, Guozhen;  Lee, Mingyuen;  Shan, Luchen;  Wang, Yuqiang;  Lin, Huangquan;  Zhang, Zaijun;  Han, Yifan
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Alzheimer's disease  tetramethylpyrazine derivative  NMDA receptor  neuroprotection  oxidative stress  GSK3 beta  
Potent Protection Against MPP+-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine Journal article
NeuroMolecular Medicine, 2016,Volume: 18,Issue: 4,Page: 561-572
Authors:  Hu S.;  Wang L.;  Mak S.;  Zhang Z.;  Xu D.;  Li H.;  Li Y.;  Hu Y.;  Lee S.M.Y.;  Wang Y.;  Han Y.
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Danshensu/tetramethylpyrazine derivative  GSK3β  MEF2D  MPP+  Neuroprotection  Parkinson’s disease  
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Zhang Z.;  Zhang G.;  Sun Y.;  Szeto S.S.W.;  Law H.C.H.;  Quan Q.;  Li G.;  Yu P.;  Sho E.;  Siu M.K.W.;  Lee S.M.Y.;  Chu I.K.;  Wang Y.
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Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models Journal article
Neurochemistry International, 2016,Volume: 99,Page: 194-205
Authors:  Xu D.;  Chen H.;  Mak S.;  Hu S.;  Tsim K.W.K.;  Hu Y.;  Sun Y.;  Zhang G.;  Wang Y.;  Zhang Z.;  Han Y.
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Alzheimer's disease  Excitotoxicity  Neurite outgrowth  Neuroprotection  Tetramethylpyrazine derivative  
Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries Journal article
European Journal of Pharmacology, 2015,Volume: 761,Page: 153-160
Authors:  Li R.W.-S.;  Yang C.;  Shan L.;  Zhang Z.;  Wang Y.;  Kwan Y.W.;  Lee S.M.Y.;  Hoi M.P.M.;  Chan S.W.;  Cheung A.C.;  Cheung K.H.;  Leung G.P.H.
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Calcium channel  Danshensu tetramethylpyrazine  Mesenteric artery  Relaxation  
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo Journal article
Biological and Pharmaceutical Bulletin, 2014,Volume: 37,Issue: 2,Page: 274-285
Authors:  Guo B.;  Xu D.;  Duan H.;  Du J.;  Zhang Z.;  Lee S.M.;  Wang Y.
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)  6-hydroxydopamine (6-OHDA)  Oxidative stress  Parkinson's disease  Tetramethylpyrazine nitrone  
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo Journal article
Biological and Pharmaceutical Bulletin, 2014,Volume: 37,Issue: 2,Page: 274-285
Authors:  Guo B.;  Xu D.;  Duan H.;  Du J.;  Zhang Z.;  Lee S.M.;  Wang Y.
Favorite  |  View/Download:2/0  |  Submit date:2018/11/06
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)  6-hydroxydopamine (6-OHDA)  Oxidative stress  Parkinson's disease  Tetramethylpyrazine nitrone  
A novel tetramethylpyrazine bis-nitrone (TN-2) protects against 6-hydroxyldopamine-induced neurotoxicity via modulation of the NF-κB and the PKCα/PI3-K/Akt pathways Journal article
Neurochemistry International, 2014,Volume: 78,Page: 76
Authors:  Xu D.-P.;  Zhang K.;  Zhang Z.-J.;  Sun Y.-W.;  Guo B.-J.;  Wang Y.-Q.;  Hoi P.-M.;  Han Y.-F.;  Lee S.M.-Y.
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6-Hydroxydopamine  Neuroinflammation  Neuroprotection  Tetramethylpyrazine derivative  
The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis Journal article
Journal of Neuroimmune Pharmacology, 2014,Volume: 9,Issue: 2,Page: 245-258
Authors:  Xu D.;  Duan H.;  Zhang Z.;  Cui W.;  Wang L.;  Sun Y.;  Lang M.;  Hoi P.M.;  Han Y.;  Wang Y.;  Lee S.M.
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Dopaminergic Neuron  Mitochondrial-dependent Apoptosis  Mptp  Parkinson's Disease