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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury Journal article
FRONTIERS IN IMMUNOLOGY, 2018,Volume: 9
Authors:  Sun, Lei;  Wu, Qiong;  Nie, Yunjuan;  Cheng, Ni;  Wang, Rui;  Wang, Gang;  Zhang, Dan;  He, Huiqiong;  Ye, Richard D.;  Qian, Fang
Favorite  |  View/Download:2/0  |  Submit date:2019/01/17
MK2  ROS  p47(phox)  neutrophils  hepatic ischemia/reperfusion injury  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury Journal article
EMBO REPORTS, 2018,Volume: 19,Issue: 10
Authors:  Cheng, Ni;  Liang, Yurong;  Du, Xiaoping;  Ye, Richard D.
View  |  Adobe PDF(2278Kb)  |  Favorite  |  View/Download:148/3  |  Submit date:2018/10/30
acute-phase response  inflammation  innate immunity  lipopolysaccharide  serum amyloid A  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View  |  Adobe PDF(2009Kb)  |  Favorite  |  View/Download:301/41  |  Submit date:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Toosendanin, a natural product, inhibited TGF-1-induced epithelial-mesenchymal transition through ERK/Snail pathway Journal article
PHYTOTHERAPY RESEARCH, 2018,Volume: 32,Issue: 10,Page: 2009-2020
Authors:  Luo, Weiwei;  Liu, Xin;  Sun, Wen;  Lu, Jin-Jian;  Wang, Yitao;  Chen, Xiuping
View  |  Adobe PDF(2621Kb)  |  Favorite  |  View/Download:241/23  |  Submit date:2018/10/30
Emt  Erk1/2  Snail  Lung Cancer  Toosendanin  
Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways Journal article
Toxicology and Applied Pharmacology, 2018,Volume: 355,Page: 1-8
Authors:  Wu X.;  Gao H.;  Hou Y.;  Yu J.;  Sun W.;  Wang Y.;  Chen X.;  Feng Y.;  Xu Q.-M.;  Chen X.
Favorite  |  View/Download:8/0  |  Submit date:2018/12/28
Dihydronortanshinone  Inflammation  Lps  Macrophage  
Tanshinone IIA attenuates insulin like growth factor 1-induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways Journal article
International Journal of Molecular Sciences, 2018,Volume: 19,Issue: 9
Authors:  Wang H.;  Su X.;  Fang J.;  Xin X.;  Zhao X.;  Gaur U.;  Wen Q.;  Xu J.;  Little P.J.;  Zheng W.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/21
Akt  Antiproliferation  ERK  IGF-1R  Tanshinone IIA  
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA Journal article
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2018,Volume: 315,Issue: 3,Page: L371-L381
Authors:  Wu, Yaxian;  He, Huiqiong;  Ding, Yunhe;  Liu, Sirui;  Zhang, Depeng;  Wang, Jun;  Jiang, Hongchao;  Zhang, Dan;  Sun, Lei;  Ye, Richard D.;  Qian, Feng
View  |  Adobe PDF(2092Kb)  |  Favorite  |  View/Download:109/7  |  Submit date:2018/10/30
acute lung injury  let-7e  lipopolysaccharides  macrophage  MAPK-activated protein kinase 2  miRNA  MK2  
GSK3-activated STAT5 regulates expression of SFRPs to modulate adipogenesis Journal article
FASEB JOURNAL, 2018,Volume: 32,Issue: 9,Page: 4714-4726
Authors:  Wang, Li;  Wang, Yuan;  Meng, Yuan;  Zhang, Chao;  Di, Lijun
Favorite  |  View/Download:249/0  |  Submit date:2018/10/30
Adipocyte Differentiation  Gsk3  Wnt Pathway