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The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism Journal article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018,Volume: 37
Authors:  Feng, Yixiao;  Wu, Mingjun;  Li, Shuman;  He, Xiaoqian;  Tang, Jun;  Peng, Weiyan;  Zeng, Beilei;  Deng, Chuxia;  Ren, Guosheng;  Xiang, Tingxiu
Favorite  |  View/Download:1/0  |  Submit date:2019/01/17
CYGB  GLUT1  HXK2  p53  Breast cancer  Metabolism  Glycolysis  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:3/0  |  Submit date:2019/01/17
LSD1  demethylase  histone  breast cancer  prostate cancer  acute myeloid leukemia  cancer therapy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite  |  View/Download:22/0  |  Submit date:2018/12/17
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation Journal article
FASEB JOURNAL, 2018,Volume: 32,Issue: 11,Page: 5874-5890
Authors:  Zheng, Can;  Chen, Dixin;  Zhang, Yan;  Bai, Yun;  Huang, Shiyang;  Zheng, Danfeng;  Liang, Weiwei;  She, Shaoping;  Peng, Xinjian;  Wang, Pingzhang;  Mo, Xiaoning;  Song, Quansheng;  Lv, Ping;  Huang, Jing;  Ye, Richard D.;  Wang, Ying
Favorite  |  View/Download:29/0  |  Submit date:2018/10/31
neural stem cell  GPCR  cytokines  
Cyanidin-3-O-β-glucoside, a Natural Polyphenol, Exerts Proapoptotic Effects on Activated Platelets and Enhances Megakaryocytic Proplatelet Formation Journal article
Journal of Agricultural and Food Chemistry, 2018,Volume: 66,Issue: 41,Page: 10712-10720
Authors:  Ya F.;  Tian J.;  Li Q.;  Chen L.;  Ren J.;  Zhao Y.;  Wan J.;  Ling W.;  Yang Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/28
anthocyanins  cyanidin-3-O-β-glucoside  megakaryocyte  platelet apoptosis  proplatelet  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
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Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
Toosendanin, a natural product, inhibited TGF-1-induced epithelial-mesenchymal transition through ERK/Snail pathway Journal article
PHYTOTHERAPY RESEARCH, 2018,Volume: 32,Issue: 10,Page: 2009-2020
Authors:  Luo, Weiwei;  Liu, Xin;  Sun, Wen;  Lu, Jin-Jian;  Wang, Yitao;  Chen, Xiuping
View  |  Adobe PDF(2621Kb)  |  Favorite  |  View/Download:241/23  |  Submit date:2018/10/30
Emt  Erk1/2  Snail  Lung Cancer  Toosendanin  
Tanshinone IIA attenuates insulin like growth factor 1-induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways Journal article
International Journal of Molecular Sciences, 2018,Volume: 19,Issue: 9
Authors:  Wang H.;  Su X.;  Fang J.;  Xin X.;  Zhao X.;  Gaur U.;  Wen Q.;  Xu J.;  Little P.J.;  Zheng W.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/21
Akt  Antiproliferation  ERK  IGF-1R  Tanshinone IIA