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TNFR2-expressing CD4+ Foxp3+ regulatory T cells in cancer immunology and immunotherapy Journal article
Progress in Molecular Biology and Translational Science, 2019
Authors:  Jiang He;  Ruixin Li;  Yibo Chen;  Yuanjia Hu;  Xin Chen
Favorite  |  View/Download:7/0  |  Submit date:2019/05/08
Regulatory t Cells  Immunotherapy  Cancer  Tumor Necrosis Factor Receptor Type 2  Tumor Necrosis Factor  
The p38 MaPK inhibitor sB203580 abrogates Tumor necrosis Factor-induced Proliferative expansion of Mouse cD4(+)Foxp3(+) regulatory T cells Journal article
FRONTIERS IN IMMUNOLOGY, 2018,Volume: 9
Authors:  He, Tianzhen;  Liu, Shuoyang;  Chen, Shaokui;  Ye, Jingyi;  Wu, Xueqiang;  Bian, Zhaoxiang;  Chen, Xin
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
tumor necrosis factor  TNF receptor type II  p38 MAPK  CD4(+)Foxp3(+) regulatory T cells  proliferation  
TNF Receptor Type II as an Emerging Drug Target for the Treatment of Cancer, Autoimmune Diseases, and Graft-Versus-Host Disease: Current Perspectives and In Silico Search for Small Molecule Binders Journal article
FRONTIERS IN IMMUNOLOGY, 2018,Volume: 9
Authors:  Shaikh, Faraz;  He, Jiang;  Bhadra, Pratiti;  Chen, Xin;  Siu, Shirley W., I
Favorite  |  View/Download:20/0  |  Submit date:2018/10/30
Tnf Receptor Type Ii  Tnf  Regulatory t Cells  Virtual Screening  Drug Discovery  Mm-pbsa  
Modulation of Regulatory T Cell Activity by TNF Receptor Type II-Targeting Pharmacological Agents Journal article
FRONTIERS IN IMMUNOLOGY, 2018,Volume: 9
Authors:  Zou, Huimin;  Li, Ruixin;  Hu, Hao;  Hu, Yuanjia;  Chen, Xin
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Tnf Receptor Type Ii  Regulatory t Cells  Tnf Receptor Type Ii Agonists  Tnf Receptor Type Ii Antagonists  Immunotherapy  
Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer Journal article
SCIENCE SIGNALING, 2018,Volume: 11,Issue: 511
Authors:  Nie, Yingjie;  He, Jiang;  Shirota, Hidekazu;  Trivett, Anna L.;  Yang, De;  Klinman, Dennis M.;  Oppenheim, Joost J.;  Chen, Xin
Favorite  |  View/Download:15/0  |  Submit date:2018/10/30
Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer Journal article
SCIENCE SIGNALING, 2017,Volume: 10,Issue: 462
Authors:  Chen, Xin;  Oppenheim, Joost J.
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis Journal article
Scientific Reports, 2016,Volume: 6
Authors:  Chen X.;  Nie Y.;  Xiao H.;  Bian Z.;  Scarzello A.J.;  Song N.-Y.;  Anna T.L.;  Yang D.;  Oppenheim J.J.
Favorite  |  View/Download:6/0  |  Submit date:2018/11/06
Tetrandrine (TET), an immunosuppressive component of Chinese herb, induces tolerogenic dendritic cells and consequently expands regulatory T cells Conference paper
JOURNAL OF IMMUNOLOGY, Seattle, WA, MAY 13-17, 2016
Authors:  Chen, X;  Oppenheim, JJ
Favorite  |  View/Download:7/0  |  Submit date:2019/01/14
IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells Journal article
FASEB Journal, 2015,Volume: 29,Issue: 2,Page: 443-454
Authors:  Chen X.;  Willette-Brown J.;  Wu X.;  Hu Y.;  Howard O.M.Z.;  Hu Y.;  Oppenheim J.J.
Favorite  |  View/Download:7/0  |  Submit date:2018/11/06
Colitis  Foxp3  Lymphopenic Mouse  Proliferation  
Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+ regulatory T cells Journal article
Immunology, 2014,Volume: 142,Issue: 2,Page: 193-201
Authors:  Hu Y.;  Xiao H.;  Shi T.;  Oppenheim J.J.;  Chen X.
Favorite  |  View/Download:6/0  |  Submit date:2018/11/06
Progranulin  Proliferation  Regulatory t Cells  Tumour Necrosis Factor  Tumour Necrosis Factor Receptor Type 2