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Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite  |  View/Download:6/0  |  Submit date:2018/10/30
aerobic glycolysis  AZD7545  dichloroacetate  LC-MS/MS  pyruvate dehydrogenase kinases  cancer metabolism  
NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth Journal article
Cancer Letters, 2015,Volume: 359,Issue: 1,Page: 97-106
Authors:  Zha X.;  Hu Z.;  Ji S.;  Jin F.;  Jiang K.;  Li C.;  Zhao P.;  Tu Z.;  Chen X.;  Di L.;  Zhou H.;  Zhang H.
Favorite  |  View/Download:0/0  |  Submit date:2018/12/21
Aerobic glycolysis  Glut3  MTOR  NFκB  Tumorigenesis  
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia Journal article
Neuroscience, 2011,Volume: 178,Page: 169-180
Authors:  Ye R.;  Zhang X.;  Kong X.;  Han J.;  Yang Q.;  Zhang Y.;  Chen Y.;  Li P.;  Liu J.;  Shi M.;  Xiong L.;  Zhao G.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/28
Ginsenoside Rd  Mitochondria  Neuroprotection  Stroke