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Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite | View/Download:26/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
The expression of ubiquitin-specific peptidase 8 and its prognostic role in patients with breast cancer Journal article
Journal of Cellular Biochemistry, 2018,Volume: 119,Issue: 12,Page: 10051-10058
Authors:  Qiu H.;  Kong J.;  Cheng Y.;  Li G.
Favorite | View/Download:14/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2019/01/15
breast cancer  clinical prognosis  ubiquitin-specific peptidase 8  
Degradation for better survival? Role of ubiquitination in epithelial morphogenesis Journal article
BIOLOGICAL REVIEWS, 2018,Volume: 93,Issue: 3,Page: 1438-1460
Authors:  Cheng, Xiaoxiang;  Zheng, Jun;  Li, Gang;  Goebel, Verena;  Zhang, Hongjie
Favorite | View/Download:29/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/10/30
Ubiquitination  E3 Ligase  Epithelial Morphogenesis  Cell Adhesion  Cell Polarity  Cytoskeleton Organization  
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
Authors:  Zhang, Le-Le;  Feng, Zhe-Ling;  Su, Min-Xia;  Jiang, Xiao-Ming;  Chen, Xiuping;  Wang, Yitao;  Li, Ao;  Lin, Li-Gen;  Lu, Jin-Jian
View | Adobe PDF | Favorite | View/Download:570/34 | TC[WOS]:13 TC[Scopus]:0 | Submit date:2018/10/30
Nagilactone e  Non-small Cell Lung Cancer  Cyclin B1  Cell Cycle  Apoptosis  
Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway Journal article
BIOMEDICINE & PHARMACOTHERAPY, 2018,Volume: 101,Page: 334-341
Authors:  Wang, Anqi;  Wang, Shengpeng;  Zhou, Fayang;  Li, Peng;  Wang, Yitao;  Gan, Lishe;  Lin, Ligen
View | Adobe PDF | Favorite | View/Download:525/20 | TC[WOS]:9 TC[Scopus]:0 | Submit date:2018/10/30
Physalin b  Breast Cancer  Cell Cycle  Apoptosis  P53  Akt  
Generation of Smurf2 conditional knockout mice Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 542-548
Authors:  Tang Y.;  Tang L.-Y.;  Xu X.;  Li C.;  Deng C.;  Zhang Y.E.
Favorite | View/Download:14/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/13
Knockout  Liver  Loxp  Mice  Smurf2  
Generation of Smurf2 conditional knockout mice Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 542-548
Authors:  Tang,Yi;  Tang,Liu Ya;  Xu,Xuan;  Li,Cuiling;  Deng,Chuxia;  Zhang,Ying E.
Favorite | View/Download:4/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Knockout  Liver  LoxP  Mice  Smurf2  
Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite | View/Download:25/0 | TC[WOS]:25 TC[Scopus]:0 | Submit date:2018/10/30
Drug Repurposing  Mitoxantrone  Nedd8  Ubiquitin  
gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction Journal article
JOURNAL OF FUNCTIONAL FOODS, 2018,Volume: 40,Page: 544-553
Authors:  Wang, Anqi;  Li, Dan;  Wang, Shengpeng;  Zhou, Fayang;  Li, Peng;  Wang, Yitao;  Lin, Ligen
View | Adobe PDF | Favorite | View/Download:521/20 | TC[WOS]:5 TC[Scopus]:0 | Submit date:2018/10/30
Gamma-mangostin  Mangosteen  Liver Oxidative Injury  Nrf2  Sirt1  Pgc-1 Alpha  
Osimertinib (AZD9291) decreases programmed death ligand-1 in EGFR-mutated non-small cell lung cancer cells Journal article
ACTA PHARMACOLOGICA SINICA, 2017,Volume: 38,Issue: 11,Page: 1512-1520
Authors:  Jiang, Xiao-Ming;  Xu, Yu-Lian;  Huang, Mu-Yang;  Zhang, Le-Le;  Su, Min-Xia;  Chen, Xiuping;  Lu, Jin-Jian
Favorite | View/Download:29/0 | TC[WOS]:16 TC[Scopus]:0 | Submit date:2018/10/30
Non-small Cell Lung Cancer  Egfr  Osimertinib  Pd-l1  Ubiquitin-proteasome System  Mg-132  Bortezomib  Gsk3 Beta  Licl