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| Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors: Xu，Biao; Wang，Zhi Peng; Liu，Qingwang; Yang，Xiaohong; Li，Xuemin; Huang，Ding; Qiu，Yanfei; Tam，Kin Yip; Zhang，Shao Lin; He，Yun
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Cancer metabolism Proliferation Pyruvate dehydrogenase kinase Structure-activity relationship |
| Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation Journal article
Theranostics, 2021,Volume: 11,Issue: 4,Page: 1672-1689
Authors: Li，Licen; Bao，Jiaolin; Wang，Haitao; Lei，Josh Haipeng; Peng，Cheng; Zeng，Jianming; Hao，Wenhui; Zhang，Xu; Xu，Xiaoling; Yu，Chundong; Deng，Chu Xia; Chen，Qiang
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AIB1 ECM Hedgehog MafB PDAC |
| Dissecting the mechanism of Yuzhi Zhixue granule on ovulatory dysfunctional uterine bleeding by network pharmacology and molecular docking Journal article
Chinese Medicine (United Kingdom), 2020,Volume: 15,Issue: 1
Authors: Li，Jialin; Luo，Hua; Liu，Xinkui; Zhang，Jingyuan; Zhou，Wei; Guo，Siyu; Chen，Xiuping ; Liu，Yingying; Jia，Shanshan; Wang，Haojia; Li，Bingbing; Cheng，Guoliang; Wu，Jiarui
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Mechanisms Molecular Docking Network pharmacology Ovulatory Dysfunctional Uterine Bleeding Yuzhi zhixue granule |
| The role of autophagy in liver cancer: Crosstalk in signaling pathways and potential therapeutic targets Journal article
Pharmaceuticals, 2020,Volume: 13,Issue: 12,Page: 1-27
Authors: Cui，Jianzhou; Shen，Han Ming; Lim，Lina Hsiu Kim
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AMPK Autophagy HCC MAPK MTOR P53 ULK1 |
| Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors: Lyu，Junfang; Yang，Eun Ju; Zhang，Baoyuan; Wu，Changjie; Pardeshi，Lakhansing; Shi，Changxiang; Mou，Pui Kei; Liu，Yifan; Tan，Kaeling; Shim，Joong Sup
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| Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 11,Page: 2054-2074
Authors: Zhu，Yuefei; Yu，Xiangrong; Thamphiwatana，Soracha D.; Zheng，Ying; Pang，Zhiqing
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Cancer immunotherapy Drug delivery Nanomedicine Tumor immunosuppressive microenvironment |
| Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids Journal article
Brain, Behavior, and Immunity, 2020,Volume: 89,Page: 604-614
Authors: Lin，Yi Wen; Chou，Ana Isabel Wu; Su，Huanxing; Su，Kuan Pin
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Amygdala Chronic pain Depression Inflammation Prefrontal cortex TRPV1 |
| Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors: Zeng，Chenming; Zhao，Chenxi; Ge，Fujing; Li，Yuekang; Cao，Ji; Ying，Meidan; Lu，Jinjian; He，Qiaojun; Yang，Bo; Dai，Xiaoyang; Zhu，Hong
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cancer therapy cellular functions deubiquitinase Machado-Joseph domain-containing proteases MJD disease |
| Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets Journal article
Frontiers in Pharmacology, 2020,Volume: 11
Authors: Zeng，Chenming; Zhao，Chenxi; Ge，Fujing; Li，Yuekang; Cao，Ji; Ying，Meidan; Lu，Jinjian; He，Qiaojun; Yang，Bo; Dai，Xiaoyang; Zhu，Hong
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cancer therapy cellular functions deubiquitinase Machado-Joseph domain-containing proteases MJD disease |
| A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets Journal article
Cell Reports, 2020,Volume: 32,Issue: 6
Authors: Zhou，Peng; Chan，Becky K.C.; Wan，Yuk Kei; Yuen，Chaya T.L.; Choi，Gigi C.G.; Li，Xinran; Tong，Cindy S.W.; Zhong，Sophia S.W.; Sun，Jieran; Bao，Yufan; Mak，Silvia Y.L.; Chow，Maggie Z.Y.; Khaw，Jien Vei; Leung，Suet Yi; Zheng，Zongli; Cheung，Lydia W.T.; Tan，Kaeling; Wong，Koon Ho; Chan，H. Y.Edwin; Wong，Alan S.L.
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cancer CombiGEM combination therapy combinatorial genetics CRISPR drug interaction genetic interaction high-throughput screening neurodegeneration Parkinson's disease |
