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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:76/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging Journal article
Photoacoustics, 2020,Volume: 19
Authors:  Liu,Yubin;  Wu,Pei Chun;  Guo,Sen;  Chou,Pi Tai;  Deng,Chuxia;  Chou,Shang Wei;  Yuan,Zhen;  Liu,Tzu Ming
Favorite | View/Download:72/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Breast cancer  FePt nanoparticles  Imaging depth  Whole-body photoacoustic imaging  
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite | View/Download:73/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 10,Page: 1279-1291
Authors:  Lei Fan;  Xiao-xia Qiu;  Zhi-yuan Zhu;  Jian-lu Lv;  Jian Lu;  Fei Mao;  Jin Zhu;  Jia-ying Wang;  Xiao-wei Guan;  Jing Chen;  Jin Ren;  Ji-ming Ye;  Yong-hua Zhao;  Jian Li;  Xu Shen
Favorite | View/Download:16/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2020/04/14
App/ps1 Transgenic Mice  Alzheimer’s Disease  Autophagy  Inflammation  Nitazoxanide  
A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation Journal article
NANOTECHNOLOGY, 2019,Volume: 30,Issue: 50
Authors:  Ke Song;  Zhaobo Wang;  Xue Liu;  Guolin Zhang;  Xin Wang;  DeFang Ouyang;  Mingrui Guo;  Lijiang Chen
Favorite | View/Download:12/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2020/03/25
Polymer-drug Conjugate  Gambogic Acid  Sensitive Drug Delivery  Cathepsin b  Glutathione  
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite | View/Download:9/0 | TC[WOS]:1 TC[Scopus]:0 | Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Nuclear localization of Desmoplakin and its involvement in telomere maintenance Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019,Volume: 15,Issue: 11,Page: 2350-2362
Authors:  Peipei Li;  Yuan Meng;  Yuan Wang;  Jingjing Li;  Manting Lam;  Li Wang;  Li-jun Di
Favorite | View/Download:14/0 | TC[WOS]:1 TC[Scopus]:0 | Submit date:2020/05/21
Crispr Bioid Telomere Dsp  
A Proresolving Peptide Nanotherapy for Site-Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota Journal article
ADVANCED SCIENCE, 2019,Volume: 6,Issue: 18
Authors:  Chenwen Li;  Yang Zhao;  Juan Cheng;  Jiawei Guo;  Qixiong Zhang;  Xiangjun Zhang;  Jiong Ren;  Fengchao Wang;  Jun Huang;  Houyuan Hu;  Ruibing Wang;  Jianxiang Zhang
Favorite | View/Download:12/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/04/02
Colitis Targeting  Gut Microbiota  Nanotherapy  Proresolving Peptide  Reactive Oxygen Species  
Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9 Journal article
NATURE METHODS, 2019,Volume: 16,Issue: 8,Page: 722–730
Authors:  Gigi C. G. Choi;  Peng Zhou;  Chaya T. L. Yuen;  Becky K. C. Chan;  Feng Xu;  Siyu Bao;  Hoi Yee Chu;  Dawn Thean;  Kaeling Tan;  Koon Ho Wong;  Zongli Zheng;  Alan S. L. Wong
Favorite | View/Download:15/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2020/05/21
Exploring effects of single-session anodal tDCS over the inferior frontal gyrus on responses to food cues and food cravings among highly disinhibited restrained eaters: A preliminary study Journal article
Neuroscience Letters, 2019,Volume: 706,Page: 211-216
Authors:  Chen,Shuaiyu;  Jackson,Todd;  Dong,Debo;  Zhang,Xuemeng;  Chen,Hong
Favorite | View/Download:10/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2019/07/08
Food cravings  Inferior frontal gyrus  Response inhibition  Restrained eaters  Transcranial direct current stimulation (tDCS)