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Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
Favorite | View/Download:21/0 | TC[WOS]:6 TC[Scopus]:0 | Submit date:2018/10/30
Aerobic Glycolysis  Azd7545  Dichloroacetate  Lc-ms/ms  Pyruvate Dehydrogenase Kinases  Cancer Metabolism  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Conference paper
Authors:  Zhang, Shao-Lin;  Zhang, Wen;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | View/Download:6/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Anti-proliferation  Binding affinity  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite | View/Download:12/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/12/18
Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase to Inhibit Cancer Proliferation Journal article
Journal of Medicinal Chemistry, 2016,Volume: 59,Issue: 7,Page: 3562-3568
Authors:  Zhang S.-L.;  Hu X.;  Zhang W.;  Tam K.Y.
Favorite | View/Download:2/0 | TC[WOS]:26 TC[Scopus]:0 | Submit date:2018/12/18
Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: Synthesis and biological evaluation Journal article
RSC Advances, 2016,Volume: 6,Issue: 82,Page: 78762-78767
Authors:  Zhang S.-L.;  Zhang W.;  Xiao Q.;  Yang Z.;  Hu X.;  Wei Z.;  Tam K.Y.
Favorite | View/Download:7/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/12/18
Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents Journal article
Drug Discovery Today, 2015,Volume: 20,Issue: 9,Page: 1112-1119
Authors:  Shao-Lin Zhang;  Xiaohui Hu;  Wen Zhang;  Huankai Yao;  Kin Yip Tam
Favorite | View/Download:8/0 | TC[WOS]:39 TC[Scopus]:0 | Submit date:2019/01/07
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite | View/Download:13/0 | TC[WOS]:57 TC[Scopus]:0 | Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
TNF-alpha, a potent lipid metabolism regulator Journal article
CELL BIOCHEMISTRY AND FUNCTION, 2009,Volume: 27,Issue: 7,Page: 407-416
Authors:  Chen, XP;  Xun, KL;  Chen, LD;  Wang, YT
View | Adobe PDF | Favorite | View/Download:480/10 | TC[WOS]:103 TC[Scopus]:0 | Submit date:2018/11/01
Tumor Necrosis Factor Alpha  Free Fatty Acid  Lipolysis  Cholesterol  Leptin  Adiponectin  Infliximab