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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships
Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:
Zhang, Shao-Lin
;
Yang, Zheng
;
Hu, Xiaohui
;
Tam, Kin Yip
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View/Download:23/0
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TC[WOS]:
2
TC[Scopus]:
2
|
Submit date:2018/10/30
Pyruvate dehydrogenase kinase
Pyruvate dehydrogenase complex
Antiproliferative activity
Dichloroacetophenone
Kinase inhibition
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:
Zhang, Shao-Lin
;
Yang, Zheng
;
Hu, Xiaohui
;
Chakravarty, Harapriya
;
Tam, Kin Yip
Favorite
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View/Download:29/0
|
TC[WOS]:
4
TC[Scopus]:
5
|
Submit date:2018/10/30
Dichloroacetophenone
Pyruvate Dehydrogenase Kinase
Pyruvate Dehydrogenase Complex
Anticancer Activity
Metabolic Reprogramming
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells
Conference paper
Authors:
Zhang, Shao-Lin
;
Zhang, Wen
;
Yang, Zheng
;
Hu, Xiaohui
;
Tam, Kin Yip
Favorite
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View/Download:9/0
|
TC[WOS]:
3
TC[Scopus]:
3
|
Submit date:2018/10/30
Pyruvate dehydrogenase kinase
Pyruvate dehydrogenase complex
Anti-proliferation
Binding affinity
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells
Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:
Zhang S.-L.
;
Zhang W.
;
Yang Z.
;
Hu X.
;
Tam K.Y.
Favorite
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View/Download:16/0
|
TC[WOS]:
3
TC[Scopus]:
3
|
Submit date:2018/12/18
Anti-proliferation
Binding affinity
Pyruvate dehydrogenase complex
Pyruvate dehydrogenase kinase
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target?
Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:
Wen Zhang
;
Shao-Lin Zhang
;
Xiaohui Hu
;
Kin Yip Tam
Favorite
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View/Download:16/0
|
TC[WOS]:
57
TC[Scopus]:
70
|
Submit date:2019/01/07
Aerobic Glycolysis
Pyruvate Dehydrogenase Kinases
Tumor Metabolism
Pyruvate Dehydrogenase Complex
TNF-alpha, a potent lipid metabolism regulator
Journal article
CELL BIOCHEMISTRY AND FUNCTION, 2009,Volume: 27,Issue: 7,Page: 407-416
Authors:
Chen, XP
;
Xun, KL
;
Chen, LD
;
Wang, YT
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View/Download:501/14
|
TC[WOS]:
103
TC[Scopus]:
119
|
Submit date:2018/11/01
Tumor Necrosis Factor Alpha
Free Fatty Acid
Lipolysis
Cholesterol
Leptin
Adiponectin
Infliximab