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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Conference paper
Authors:  Zhang, Shao-Lin;  Zhang, Wen;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:3/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Anti-proliferation  Binding affinity  
Targeting tumor metabolism for cancer treatment: Is pyruvate dehydrogenase kinases (PDKs) a viable anticancer target? Journal article
International Journal of Biological Sciences, 2015,Volume: 11,Issue: 12,Page: 1390-1400
Authors:  Wen Zhang;  Shao-Lin Zhang;  Xiaohui Hu;  Kin Yip Tam
Favorite  |  View/Download:2/0  |  Submit date:2019/01/07
Aerobic Glycolysis  Pyruvate Dehydrogenase Kinases  Tumor Metabolism  Pyruvate Dehydrogenase Complex  
TNF-alpha, a potent lipid metabolism regulator Journal article
CELL BIOCHEMISTRY AND FUNCTION, 2009,Volume: 27,Issue: 7,Page: 407-416
Authors:  Chen, XP;  Xun, KL;  Chen, LD;  Wang, YT
View  |  Adobe PDF(231Kb)  |  Favorite  |  View/Download:87/3  |  Submit date:2018/11/01
Tumor Necrosis Factor Alpha  Free Fatty Acid  Lipolysis  Cholesterol  Leptin  Adiponectin  Infliximab