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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:5/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics Journal article
Nanoscale Horizons, 2019
Authors:  Zhen Yang;  Yunlu Dai;  Lingling Shan;  Zheyu Shen;  Zhantong Wang;  Bryant C. Yung;  Orit Jacobson;  Yijing Liu;  Wei Tang;  Sheng Wang;  Lisen Lin;  Gang Niu;  Pintong Huang;  Xiaoyuan Chen
Favorite  |  View/Download:14/0  |  Submit date:2019/01/25
Hybrid Nanomedicine Fabricated from Photosensitizer-Terminated Metal-Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy Journal article
SMALL, 2018,Volume: 15,Issue: 4
Authors:  Zhimei He;  Yunlu Dai;  Xiangli Li;  Dan Guo;  Yijing Liu;  Xiaolin Huang;  Jingjing Jiang;  Sheng Wang;  Guizhi Zhu;  Fuwu Zhang;  Lisen Lin;  Jun‐Jie Zhu;  Guocan Yu;  Xiaoyuan Chen
Favorite  |  View/Download:45/0  |  Submit date:2020/05/13
Banoxantrone  Cascade Therapy  Hypoxia-activated Prodrugs  Nanoscale Metal-organic Frameworks  Photodynamic Therapy  
Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo Journal article
Advanced Materials, 2018,Volume: 30,Issue: 23
Authors:  Yang Z.;  Dai Y.;  Yin C.;  Fan Q.;  Zhang W.;  Song J.;  Yu G.;  Tang W.;  Fan W.;  Yung B.C.;  Li J.;  Li X.;  Li X.;  Tang Y.;  Huang W.;  Song J.;  Chen X.
Favorite  |  View/Download:18/0  |  Submit date:2019/01/15
Cisplatin  Ratiometric Photoacoustic Imaging  Ros Generation  Synergistic Cancer Therapy  Theranostics  
Toxic Reactive Oxygen Species Enhanced Synergistic Combination Therapy by Self-Assembled Metal-Phenolic Network Nanoparticles Journal article
Advanced Materials, 2018,Volume: 30,Issue: 8
Authors:  Dai Y.;  Yang Z.;  Cheng S.;  Wang Z.;  Zhang R.;  Zhu G.;  Wang Z.;  Yung B.C.;  Tian R.;  Jacobson O.;  Xu C.;  Ni Q.;  Song J.;  Sun X.;  Niu G.;  Chen X.
Favorite  |  View/Download:12/0  |  Submit date:2019/01/15
Combination Therapy  Metal-polyphenol Networks  Positron Emission Tomography  Reactive Oxygen Species  Self-assembly  
One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy Journal article
BIOMATERIALS, 2018,Volume: 156,Page: 121-133
Authors:  Yang, Yu;  Xu, Ligeng;  Zhu, Wenjun;  Feng, Liangzhu;  Liu, Jingjing;  Chen, Qian;  Dong, Ziliang;  Zhao, Jiayue;  Liu, Zhuang;  Chen, Meiwan
Favorite  |  View/Download:21/0  |  Submit date:2018/10/30
Nanoscale Coordination Polymers (Ncps)  One-pot Synthesis  Carrier-free Drug Delivery System  Ph-responsive Charge-switching  Chemotherapy  
Hypochlorous Acid Promoted Platinum Drug Chemotherapy by Myeloperoxidase-Encapsulated Therapeutic Metal Phenolic Nanoparticles Journal article
ACS Nano, 2018,Volume: 12,Issue: 1,Page: 455-463
Authors:  Dai Y.;  Cheng S.;  Wang Z.;  Zhang R.;  Yang Z.;  Wang J.;  Yung B.C.;  Wang Z.;  Jacobson O.;  Xu C.;  Ni Q.;  Yu G.;  Zhou Z.;  Chen X.
Favorite  |  View/Download:7/0  |  Submit date:2019/01/15
Cisplatin  Hypochlorous Acid (Hocl)  Metal-polyphenol Networks  Myeloperoxidase (Mpo)  Positron Emission Tomography  
Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene–Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules Journal article
Angewandte Chemie - International Edition, 2018,Volume: 57,Issue: 1,Page: 177-181
Authors:  Dong Q.;  Wang X.;  Hu X.;  Xiao L.;  Zhang L.;  Song L.;  Xu M.;  Zou Y.;  Chen L.;  Chen Z.;  Tan W.
Favorite  |  View/Download:8/0  |  Submit date:2019/02/13
aspirin  graphitic nanocapsules  inflammation  photothermal therapy  prodrugs  
Simultaneous Application of Photothermal Therapy and an Anti-inflammatory Prodrug using Pyrene-Aspirin-Loaded Gold Nanorod Graphitic Nanocapsules Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 1,Page: 177-181
Authors:  Dong, Qian;  Wang, Xuewei;  Hu, Xiaoxiao;  Xiao, Langqiu;  Zhang, Liang;  Song, Lijuan;  Xu, Minglu;  Zou, Yuxiu;  Chen, Long;  Chen, Zhuo;  Tan, Weihong
Favorite  |  View/Download:31/0  |  Submit date:2018/10/30
aspirin  graphitic nanocapsules  inflammation  photothermal therapy  prodrugs  
Hybrid Nanomedicine Fabricated from Photosensitizer‐Terminated Metal–Organic Framework Nanoparticles for Photodynamic Therapy and Hypoxia‐Activated Cascade Chemotherapy Journal article
small, 2018,Volume: 15,Issue: 4
Authors:  Zhimei He;  Yunlu Dai;  Xiangli Li;  Dan Guo;  Yijing Liu;  Xiaolin Huang;  Jingjing Jiang;  Sheng Wang;  Guizhi Zhu;  Fuwu Zhang;  Lisen Lin;  Jun‐Jie Zhu;  Guocan Yu;  Xiaoyuan Chen
Favorite  |  View/Download:8/0  |  Submit date:2019/01/28
Banoxantrone  Cascade Therapy  Hypoxia‐activated Prodrugs  Nanoscale Metal–organic Frameworks  Photodynamic Therapy