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γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis Journal article
Toxicology and Applied Pharmacology, 2019,Volume: 363,Page: 142-153
Authors:  Wang A.;  Zhou F.;  Li D.;  Lu J.-J.;  Wang Y.;  Lin L.
Favorite  |  View/Download:8/0  |  Submit date:2018/12/28
Fibrogenesis  HMGB1  Liver fibrosis  Sirtuin 3  Superoxide  γ-Mangostin  
Comparative comprehension on the anti-rheumatic Chinese herbal medicine Siegesbeckiae Herba: Combined computational predictions and experimental investigations Journal article
Journal of Ethnopharmacology, 2019,Volume: 228,Page: 200-209
Authors:  Zhang Q.R.;  Zhong Z.F.;  Sang W.;  Xiong W.;  Tao H.X.;  Zhao G.D.;  Li Z.X.;  Ma Q.S.;  Tse A.K.W.;  Hu Y.J.;  Yu H.;  Wang Y.T.
Favorite  |  View/Download:10/0  |  Submit date:2018/12/28
Computational prediction  Difference  Rheumatoid arthritis  Siegesbeckiae Herba  Similarity  
Preparative separation of minor saponins from Panax notoginseng leaves using biotransformation, macroporous resins, and preparative high-performance liquid chromatography Journal article
JOURNAL OF GINSENG RESEARCH, 2019,Volume: 43,Issue: 1,Page: 105-115
Authors:  Liu, Fang;  Ma, Ni;  Xia, Fang-Bo;  Li, Peng;  He, Chengwei;  Wu, Zhenqiang;  Wan, Jian-Bo
Favorite  |  View/Download:0/0  |  Submit date:2019/01/17
ginsenoside Rd2  gypenoside XVII  notoginsenoside Fd  notoginsenoside Fe  Panax notoginseng leaves  
Tetrandrine inhibits differentiation of proinflammatory subsets of T helper cells but spares de novo differentiation of iTreg cells Journal article
INTERNATIONAL IMMUNOPHARMACOLOGY, 2019,Volume: 69,Page: 307-312
Authors:  Zou, HM;  He, TZ;  Chen, X
Favorite  |  View/Download:2/0  |  Submit date:2019/05/08
Tetrandrine  Itreg Cells  Th17 Cells  Th2 Cells  Th1 Cells  
Fighting Liver Fibrosis with Naturally Occurring Antioxidants Journal article
PLANTA MEDICA, 2018,Volume: 84,Issue: 18,Page: 1318-1333
Authors:  Lin, Ligen;  Zhou, Fayang;  Shen, Shengnan;  Zhang, Tian
Favorite  |  View/Download:3/0  |  Submit date:2019/01/17
liver fibrosis  antioxidants  oxidative stress  reactive oxygen species  hepatic stellate cells  natural products  
Trends of Polypharmacy and Prescription Patterns of Antidepressants in Asia Journal article
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2018,Volume: 38,Issue: 6,Page: 598-603
Authors:  Huang, Cho-Yin;  Yang, Shu-Yu;  Mojtabai, Ramin;  Lin, Shu-Ku;  He, Yan-Ling;  Chong, Mian-Yoon;  Ungvari, Gabor;  Tan, Chay-Hoon;  Xiang, Yu-Tao;  Sartorius, Norman;  Shinfuku, Naotaka;  Chen, Lian-Yu
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antidepressant use  polypharmacy  prescription pattern  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
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Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Editorial, IAPC-6 Meeting Journal article
PHARMACEUTICAL RESEARCH, 2018,Volume: 35,Issue: 11
Authors:  Tam, Kin;  Li, Tonglei;  Mandic, Zoran
Favorite  |  View/Download:0/0  |  Submit date:2019/01/17