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Nagilactone E suppresses TGF-β1-induced epithelial–mesenchymal transition, migration and invasion in non-small cell lung cancer cells Journal article
Phytomedicine, 2019,Volume: 52,Page: 32-39
Authors:  Zhang L.-L.;  Jiang X.-M.;  Huang M.-Y.;  Feng Z.-L.;  Chen X.;  Wang Y.;  Li H.;  Li A.;  Lin L.-G.;  Lu J.-J.
Favorite  |  View/Download:9/0  |  Submit date:2018/12/28
Epithelial-mesenchymal transition  Nagilactone E  Smad  TGF-β1  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA Journal article
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2018,Volume: 315,Issue: 3,Page: L371-L381
Authors:  Wu, Yaxian;  He, Huiqiong;  Ding, Yunhe;  Liu, Sirui;  Zhang, Depeng;  Wang, Jun;  Jiang, Hongchao;  Zhang, Dan;  Sun, Lei;  Ye, Richard D.;  Qian, Feng
View  |  Adobe PDF(2092Kb)  |  Favorite  |  View/Download:92/6  |  Submit date:2018/10/30
acute lung injury  let-7e  lipopolysaccharides  macrophage  MAPK-activated protein kinase 2  miRNA  MK2  
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
Authors:  Zhang, Le-Le;  Feng, Zhe-Ling;  Su, Min-Xia;  Jiang, Xiao-Ming;  Chen, Xiuping;  Wang, Yitao;  Li, Ao;  Lin, Li-Gen;  Lu, Jin-Jian
View  |  Adobe PDF(3226Kb)  |  Favorite  |  View/Download:124/17  |  Submit date:2018/10/30
Nagilactone e  Non-small Cell Lung Cancer  Cyclin B1  Cell Cycle  Apoptosis  
B-Myb Mediates Proliferation and Migration of Non-Small-Cell Lung Cancer via Suppressing IGFBP3 Journal article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018,Volume: 19,Issue: 5
Authors:  Fan, Xiaoyan;  Wang, Yitao;  Jiang, Tinghui;  Cai, Wei;  Jin, Yuelei;  Niu, Yulong;  Zhu, Huifang;  Bu, Youquan
Favorite  |  View/Download:1/0  |  Submit date:2018/11/01
B-Myb  IGFBP3  NSCLC  proliferation  motility  
Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-beta-Smad signaling pathway Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 341,Page: 38-50
Authors:  Zhou, Fayang;  Wang, Anqi;  Li, Dan;  Wang, Yitao;  Lin, Ligen
View  |  Adobe PDF(2014Kb)  |  Favorite  |  View/Download:91/7  |  Submit date:2018/10/30
Liver Fibrosis  Hepatic Stellate Cells  Penthorum Chinense Pursh  Pinocembrin  Sma- And Mad-related Proteins  Silent Mating Type Information Regulation 2 Homolog 3  
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 2,Page: 204-216
Authors:  Yang, Zheng;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Combination  Egfr-tki  Nsclc  Chemotherapy  Targeted Therapy  Immunotherapy  
Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies Journal article
CANCER LETTERS, 2018,Volume: 420,Page: 242-246
Authors:  Tang, Zheng-Hai;  Lu, Jin-Jian
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Osimertinib  Azd9291  Egfr Tki  Resistant Mechanisms  Therapeutic Strategies  
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer Journal article
CANCER LETTERS, 2018,Volume: 412,Page: 1-9
Authors:  Tang, Zheng-Hai;  Cao, Wen-Xiang;  Guo, Xia;  Dai, Xiao-Yang;  Lu, Jia-Hong;  Chen, Xiuping;  Zhu, Hong;  Lu, Jin-Jian
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Cepharanthine  Autophagy  Lysosome  Dacomitinib  Nsclc  
Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2018,Volume: 18,Issue: 4,Page: 550-555
Authors:  Tang Z.-H.;  Su M.-X.;  Guo X.;  Jiang X.-M.;  Jia L.;  Chen X.;  Lu J.-J.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/28
Azd9291  Egfr  Ire1α  Lune Cancer  Nsclc  Osimertinib