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Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Archives of Toxicology, 2019,Volume: 93,Issue: 1,Page: 189-206
Authors:  Liao Q.;  Li S.;  Siu S.W.I.;  Morlighem J.-E.R.L.;  Wong C.T.T.;  Wang X.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:17/0  |  Submit date:2019/04/04
Anti-epilepsy  Disulfide Bond  Neuroactive Peptides  Neuroprotection  Protein Docking  Voltage-gated Sodium Ion Channel Blocker  
Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction Journal article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018,Volume: 66,Issue: 31,Page: 8307-8318
Authors:  Li, Chuwen;  Tang, Benqin;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  Su, Ziren;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:17/0  |  Submit date:2018/10/31
Pinostrobin  Parkinson's Disease  Neurotoxin  Nrf2  
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
View  |  Adobe PDF(3018Kb)  |  Favorite  |  View/Download:355/13  |  Submit date:2018/10/30
Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite  |  View/Download:29/0  |  Submit date:2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB Journal article
Frontiers in Pharmacology, 2018,Volume: 9,Issue: JUN
Authors:  Li C.;  Chen T.;  Zhou H.;  Feng Y.;  Hoi M.P.M.;  Ma D.;  Zhao C.;  Zheng Y.;  Lee S.M.Y.
Favorite  |  View/Download:10/0  |  Submit date:2018/11/06
BHDPC  CREB  Microglia  Neuroinflammation  NF-κB  PKA  
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
View  |  Adobe PDF(3535Kb)  |  Favorite  |  View/Download:391/21  |  Submit date:2018/10/30
An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
A novel ShK-like toxic peptide fromthe transcriptome of the cnidarian Palythoa caribaeorum displays neuroprotection and cardioprotection in zebrafish Journal article
Toxins, 2018,Volume: 10,Issue: 6
Authors:  Liao Q.;  Gong G.;  Siu S.W.I.;  Wong C.T.T.;  Yu H.;  Tse Y.C.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:8/0  |  Submit date:2018/11/06
Animal toxins  Calcium-activated K+ ion channel  Dynamics simulation  ShK-like peptide  Voltage-gated K+ ion channel  Zoantharian  
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish Journal article
TOXINS, 2018,Volume: 10,Issue: 6
Authors:  Liao, Qiwen;  Gong, Guiyi;  Siu, Shirley Weng In;  Wong, Clarence Tsun Ting;  Yu, Huidong;  Tse, Yu Chung;  Radis-Baptista, Gandhi;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:26/0  |  Submit date:2018/10/30
Zoantharian  Shk-like Peptide  Dynamics Simulation  Voltage-gated K++ Ion Channel  Calcium-activated K++ Ion Channel  Animal Toxins  
Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKK beta-Dependent AMPK Activation Journal article
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018,Volume: 11
Authors:  Li, Chuwen;  Zhang, Chao;  Zhou, Hefeng;  Feng, Yu;  Tang, Fan;  Hoi, Maggie P. M.;  He, Chengwei;  Ma, Dan;  Zhao, Chao;  Lee, Simon M. Y.
Favorite  |  View/Download:27/0  |  Submit date:2018/10/30
Amp-activated Protein Kinase  Betulinic Acid  Calmodulin-dependent Protein Kinase Beta  Microglia Polarization  Neuroinflammation  
Inhibitory effects of betulinic acid on LPS-induced neuroinflammation involve M2 microglial polarization via CaMKKβ-dependent AMPK activation Journal article
Frontiers in Molecular Neuroscience, 2018,Volume: 11
Authors:  Li C.;  Zhang C.;  Zhou H.;  Feng Y.;  Tang F.;  Hoi M.P.M.;  He C.;  Ma D.;  Zhao C.;  Lee S.M.Y.
Favorite  |  View/Download:10/0  |  Submit date:2018/11/06
AMP-activated protein kinase  Betulinic acid  Calmodulin-dependent protein kinase β  Microglia polarization  Neuroinflammation