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Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia) Journal article
ARCHIVES OF TOXICOLOGY, 2019,Volume: 93,Issue: 6,Page: 1745-1767
Authors:  Qiwen Liao;  Guiyi Gong;  Terence C. W. Poon;  Irene L. Ang;  Kate M. K. Lei;  Shirley Weng In Siu;  Clarence Tsun Ting Wong;  Gandhi Rádis-Baptista;  Simon Ming-Yuen Lee
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Cnidaria  Neuroprotection  Proteomic  Transcriptomic  Venom-derived Peptide  Zoantharian  
Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization Journal article
ACS CHEMICAL NEUROSCIENCE, 2019,Volume: 10,Issue: 5,Page: 2434-2449
Authors:  Chuwen Li;  Yaqi Bian;  Yu Feng;  Fan Tang;  Liang Wang;  Maggie Pui Man Hoi;  Dan Ma;  Chao Zhao;  Simon Ming Yuen Lee
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Bhdpc  Ischemic Stroke  Microglia  Nf-κb  Creb  Pka  
Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Archives of Toxicology, 2019,Volume: 93,Issue: 1,Page: 189-206
Authors:  Liao Q.;  Li S.;  Siu S.W.I.;  Morlighem J.-E.R.L.;  Wong C.T.T.;  Wang X.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:13/0  |  Submit date:2019/04/04
Anti-epilepsy  Disulfide bond  Neuroactive peptides  Neuroprotection  Protein docking  Voltage-gated sodium ion channel blocker  
Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction Journal article
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018,Volume: 66,Issue: 31,Page: 8307-8318
Authors:  Li, Chuwen;  Tang, Benqin;  Feng, Yu;  Tang, Fan;  Hoi, Maggie Pui-Man;  Su, Ziren;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:13/0  |  Submit date:2018/10/31
Pinostrobin  Parkinson's Disease  Neurotoxin  Nrf2  
BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappa B and Activating PKA/CREB Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Li, Chuwen;  Chen, Tongkai;  Zhou, Hefeng;  Feng, Yu;  Hoi, Maggie P. M.;  Ma, Dan;  Zhao, Chao;  Zheng, Ying;  Lee, Simon M. Y.
Favorite  |  View/Download:27/0  |  Submit date:2018/10/30
Bhdpc  Neuroinflammation  Microglia  Nf-kappa b  Creb  Pka  
BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB Journal article
Frontiers in Pharmacology, 2018,Volume: 9,Issue: JUN
Authors:  Li C.;  Chen T.;  Zhou H.;  Feng Y.;  Hoi M.P.M.;  Ma D.;  Zhao C.;  Zheng Y.;  Lee S.M.Y.
Favorite  |  View/Download:8/0  |  Submit date:2018/11/06
BHDPC  CREB  Microglia  Neuroinflammation  NF-κB  PKA  
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor Journal article
Nanoscale, 2018,Volume: 10,Issue: 22,Page: 10333-10336
Authors:  Huang Q.;  Kuok K.I.;  Zhang X.;  Yue L.;  Lee S.M.Y.;  Zhang J.;  Wang R.
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UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
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An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
A novel ShK-like toxic peptide fromthe transcriptome of the cnidarian Palythoa caribaeorum displays neuroprotection and cardioprotection in zebrafish Journal article
Toxins, 2018,Volume: 10,Issue: 6
Authors:  Liao Q.;  Gong G.;  Siu S.W.I.;  Wong C.T.T.;  Yu H.;  Tse Y.C.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/11/06
Animal toxins  Calcium-activated K+ ion channel  Dynamics simulation  ShK-like peptide  Voltage-gated K+ ion channel  Zoantharian  
A Novel ShK-Like Toxic Peptide from the Transcriptome of the Cnidarian Palythoa caribaeorum Displays Neuroprotection and Cardioprotection in Zebrafish Journal article
TOXINS, 2018,Volume: 10,Issue: 6
Authors:  Liao, Qiwen;  Gong, Guiyi;  Siu, Shirley Weng In;  Wong, Clarence Tsun Ting;  Yu, Huidong;  Tse, Yu Chung;  Radis-Baptista, Gandhi;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:22/0  |  Submit date:2018/10/30
zoantharian  ShK-like peptide  dynamics simulation  voltage-gated K+ ion channel  calcium-activated K+ ion channel  animal toxins