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Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish Journal article
Archives of Toxicology, 2019,Volume: 93,Issue: 1,Page: 189-206
Authors:  Liao Q.;  Li S.;  Siu S.W.I.;  Morlighem J.-E.R.L.;  Wong C.T.T.;  Wang X.;  Radis-Baptista G.;  Lee S.M.-Y.
Favorite  |  View/Download:6/0  |  Submit date:2019/04/04
Anti-epilepsy  Disulfide bond  Neuroactive peptides  Neuroprotection  Protein docking  Voltage-gated sodium ion channel blocker  
A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population Journal article
Neurobiology of Aging, 2018,Volume: 68,Page: 160.e1-160.e7
Authors:  Wang B.;  Bao S.;  Zhang Z.;  Zhou X.;  Wang J.;  Fan Y.;  Zhang Y.;  Li Y.;  Chen L.;  Jia Y.;  Li J.;  Li M.;  Zheng W.;  Mu N.;  Wang L.;  Yu Z.;  Wong D.S.M.;  Zhang Y.;  Kwan J.;  Ka-Fung Mak H.;  Ambalavanan A.;  Zhou S.;  Cai W.;  Zheng J.;  Huang S.;  Rouleau G.A.;  Yang W.;  Rogaeva E.;  Ma X.;  St George-Hyslop P.;  Chu L.W.;  Song Y.-Q.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/21
Apoe Ɛ4-negative  Late-onset Alzheimer's Disease  Mlkl  Whole Exome Sequencing  
HAMdb: a database of human autophagy modulators with specific pathway and disease information Journal article
JOURNAL OF CHEMINFORMATICS, 2018,Volume: 10
Authors:  Wang, Ning-Ning;  Dong, Jie;  Zhang, Lin;  Ouyang, Defang;  Cheng, Yan;  Chen, Alex F.;  Lu, Ai-Ping;  Cao, Dong-Sheng
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Autophagy  Autophagy modulator  Database  Disease  Pathophysiological  Pathway  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 101-108
Authors:  Wu X.;  Kosaraju J.;  Tam K.Y.
Favorite  |  View/Download:10/0  |  Submit date:2018/12/18
Alzheimer's Disease  Glycogen Synthase Kinase-3β  Okadaic Acid  Slm  Tau Hyperphosphorylation  
SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3 beta activity in SH-SY5Y cells Conference paper
Authors:  Wu, Xiaoli;  Kosaraju, Jayasankar;  Tam, Kin Yip
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Tau hyperphosphorylation  Alzheimer's disease  SLM  Okadaic acid  Glycogen synthase kinase-3 beta  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View  |  Adobe PDF(2766Kb)  |  Favorite  |  View/Download:213/5  |  Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway Journal article
Cellular and Molecular Neurobiology, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu J.;  Zheng J.;  Lin J.;  Jin L.;  Yu R.;  Mak S.;  Hu S.;  Sun H.;  Wu X.;  Zhang Z.;  Lee M.;  Tsim W.;  Su W.;  Zhou W.;  Cui W.;  Han Y.;  Wang Q.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
ERK  GSK3β  H2O2  Indirubin-3-oxime  PI3-K  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
Favorite  |  View/Download:15/0  |  Submit date:2018/10/30
Indirubin-3-oxime  H2O2  GSK3 beta  PI3-K  ERK  
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy Journal article
AUTOPHAGY, 2017,Volume: 13,Issue: 11,Page: 1969-1980
Authors:  Chen, Lei-Lei;  Wang, Yong-Bo;  Song, Ju-Xian;  Deng, Wan-Kun;  Lu, Jia-Hong;  Ma, Li-Li;  Yang, Chuan-Bin;  Li, Min;  Xue, Yu
Favorite  |  View/Download:14/0  |  Submit date:2018/10/30
autophagy  corynoxine  kinase activity  phosphoproteome  phosphorylation  protein kinase  
ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders Journal article
CURRENT DRUG TARGETS, 2017,Volume: 18,Issue: 4,Page: 455-462
Authors:  Chong, Cheong-Meng;  Ai, Nana;  Lee, Simon Ming-Yuen
Favorite  |  View/Download:13/0  |  Submit date:2018/10/30
Axonal Regeneration  Central Nervous System  Fasudil  Isoforms  Limk  Neurodegenerative Diseases  Rock