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Key Molecules and Pathways Underlying Sporadic Amyotrophic Lateral Sclerosis: Integrated Analysis on Gene Expression Profiles of Motor Neurons Journal article
Frontiers in Genetics, 2020,Volume: 11
Authors:  Lin,Jianing;  Huang,Pian;  Chen,Weineng;  Ye,Chenghui;  Su,Huanxing;  Yao,Xiaoli
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bioinformatics analysis  FN1 gene  gene expression profiles  motor neurons  sporadic amyotrophic lateral sclerosis  
An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease Journal article
ACS Chemical Neuroscience, 2020,Volume: 11,Issue: 20,Page: 3346-3357
Authors:  Ju,Yaojun;  Chakravarty,Harapriya;  Tam,Kin Yip
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Alzheimer's disease  amyloid beta  cholinesterase  dual inhibition  
Oxyphylla a promotes degradation of α-synuclein for neuroprotection via activation of immunoproteasome Journal article
Aging and Disease, 2020,Volume: 11,Issue: 3,Page: 559-574
Authors:  Zhou,Hefeng;  Li,Shengnan;  Li,Chuwen;  Yang,Xuanjun;  Li,Haitao;  Zhong,Hanbing;  Lu,Jia Hong;  Lee,Simon Ming Yuen
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Degradation  Neuroprotection  Parkinson's disease  Proteasome  α-synuclein  
Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma Journal article
BMC Medical Genomics, 2020,Volume: 13,Issue: 1
Authors:  Zheng P.;  Huang C.;  Leng D.;  Sun B.;  Zhang X.D.
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Childhood asthma  Deep RNA-sequencing  Long non-coding RNAs  Transcriptome  
Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models Journal article
Neurotherapeutics, 2019,Volume: 16,Issue: 4,Page: 1225-1236
Authors:  Zhou,Hefeng;  Shao,Min;  Guo,Baojian;  Li,Chuwen;  Lu,Yucong;  Yang,Xuanjun;  ShengnanLi,;  Li,Haitao;  Zhu,Qi;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lu,Jiahong;  Lee,Simon Ming Yuen
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Degradation  LMP7  Parkinson’s disease  Proteasome activity  α-synuclein  
Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation Journal article
Phytomedicine, 2019,Volume: 61
Authors:  Cai,Cui Zan;  Zhou,He Feng;  Yuan,Ning Ning;  Wu,Ming Yue;  Lee,Simon Ming Yuen;  Ren,Jiao Yan;  Su,Huan Xing;  Lu,Jin Jian;  Chen,Xiu Ping;  Li,Min;  Tan,Jie Qiong;  Lu,Jia Hong
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-synuclein  Harmine  Parkinson's disease  Protein kinase A  Ubiquitin-proteasome system  
Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
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Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson's Disease In Vitro and In Vivo Journal article
Oxidative Medicine and Cellular Longevity, 2019,Volume: 2019
Authors:  Zhou,Hefeng;  Shao,Min;  Yang,Xuanjun;  Li,Chuwen;  Cui,Guozhen;  Gao,Cheng;  Di,Lijun;  Zhong,Hanbing;  Wang,Yuqiang;  Zhang,Zaijun;  Lee,Simon Ming Yuen
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Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis Journal article
CARDIOVASCULAR THERAPEUTICS, 2018,Volume: 36,Issue: 5
Authors:  Yuan, Rong;  Xin, Qiqi;  Shi, Weili;  Liu, Wei;  Lee, Simon-M.;  Hoi, Puiman;  Li, Lin;  Zhao, Jun;  Cong, Weihong;  Chen, Keji
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Angina Pectoris  Angiogenesis Inducing Agents  Coronary Artery Disease  Genetic Therapy  Myocardial Ischemia  Vascular Endothelial Growth Factor  
Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease Journal article
ORPHANET JOURNAL OF RARE DISEASES, 2018,Volume: 13
Authors:  Vu, Mylinh;  Li, Rong;  Baskfield, Amanda;  Lu, Billy;  Farkhondeh, Atena;  Gorshkov, Kirill;  Motabar, Omid;  Beers, Jeanette;  Chen, Guokai;  Zou, Jizhong;  Espejo-Mojica, Angela J.;  Rodriguez-Lopez, Alexander;  Almeciga-Diaz, Carlos J.;  Barrera, Luis A.;  Jiang, Xuntian;  Ory, Daniel S.;  Marugan, Juan J.;  Zheng, Wei
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Tay-sachs Disease  Induced Pluripotent Stem Cells  Neural Stem Cells  Cyclodextrin  Hp Beta Cd  Delta-tocopherol  Enzyme Replacement Therapy  Hexosaminidase a  Gm2 Gangliosidosis  High Throughput Screening  Drug Discovery