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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:8/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Metformin protects PC12 cells and hippocampal neurons from H2O (2)-induced oxidative damage through activation of AMPK pathway Journal article
JOURNAL OF CELLULAR PHYSIOLOGY, 2019,Volume: 234,Issue: 9,Page: 16619-16629
Authors:  Xia Zhao;  Zhiwen Zeng;  Uma Gaur;  Jiankang Fang;  Tangming Peng;  Shuai Li;  Wenhua Zheng
Favorite  |  View/Download:8/0  |  Submit date:2020/06/11
Aging  Amp-activated Protein Kinase  Hydrogen Peroxide  Metformin  Pc12 Cells  
Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
STEM CELL REPORTS, 2019,Volume: 13,Issue: 2,Page: 338-351
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng;  Yiqi Yang;  Shreyas Lingadahalli;  Edwin Cheung;  Gang Li;  Weiwei Liu;  Jianbo Wan;  Yang Zhao;  Guokai Chen
Favorite  |  View/Download:13/0  |  Submit date:2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation  
Self-Assembled Metal-Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer Journal article
ADVANCED BIOSYSTEMS, 2019,Volume: 3,Issue: 2
Authors:  Ke Li;  Yunlu Dai;  Wen Chen;  Kang Yu;  Gao Xiao;  Joseph J. Richardson;  Wen Huang;  Junling Guo;  Xuepin Liao;  Bi Shi
Favorite  |  View/Download:35/0  |  Submit date:2020/05/13
Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance Journal article
BRITISH JOURNAL OF PHARMACOLOGY, 2019,Volume: 176,Issue: 20,Page: 3983-4001
Authors:  Shen, SN;  Liao, QW;  Zhang, T;  Pan, RL;  Lin, LG
Favorite  |  View/Download:12/0  |  Submit date:2020/03/20
MnSOD mediates shear stress-promoted tumor cell migration and adhesion Journal article
FREE RADICAL BIOLOGY AND MEDICINE, 2018,Volume: 129,Page: 46-58
Authors:  Ma, Shijun;  Fu, Afu;  Lim, Sierin;  Chiew, Geraldine Giap Ying;  Luo, Kathy Qian
Favorite  |  View/Download:10/0  |  Submit date:2019/01/17
Shear stress  Tumor cell adhesion  Tumor cell migration  Reactive oxygen species  MnSOD  FAK  
Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer Journal article
Advanced Biosystems, 2018,Issue: 1800241
Authors:  Ke Li;  Yunlu Dai;  Wen Chen;  Kang Yu;  Gao Xiao;  Joseph J. Richardson;  Wen Huang;  Junling Guo;  Xuepin Liao;  Bi Shi
Favorite  |  View/Download:13/0  |  Submit date:2019/01/28
Colon Cancer  Combination Therapy  Metal‐phenolic Networks  Rare Earth  Ros  
Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer Journal article
Cell Reports, 2018,Volume: 25,Issue: 8,Page: 2285-2298.e4
Authors:  Zhu D.;  Zhao Z.;  Cui G.;  Chang S.;  Hu L.;  See Y.X.;  Lim M.G.L.;  Guo D.;  Chen X.;  Robson P.;  Luo Y.;  Cheung E.
Favorite  |  View/Download:13/0  |  Submit date:2018/12/17
Breast Cancer  Estrogen Receptor α  Metabolic Switch  Single-cell Rna Sequencing  
Acetaminophen-induced liver injury is attenuated in transgenic fat-1 mice endogenously synthesizing long-chain n-3 fatty acids Journal article
BIOCHEMICAL PHARMACOLOGY, 2018,Volume: 154,Page: 75-88
Authors:  Feng, Ruibing;  Wang, Yang;  Liu, Conghui;  Yan, Chunyan;  Zhang, Hang;  Su, Huanxing;  Kang, Jing X.;  Shang, Chang-Zhen;  Wan, Jim-Bo
Favorite  |  View/Download:22/0  |  Submit date:2018/10/30
Acetaminophen  N-3 Polyunsaturated Fatty Acids  Hepatotoxicity  Jnk  Inflammatory  
A novel Ca2+ current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 134,Page: 109-117
Authors:  Cui, Guozhen;  Xin, Qiqi;  Tseng, Hisa Hui Ling;  Hoi, Maggie PuiMan;  Wang, Yan;  Yang, Binrui;  Choi, InLeng;  Wang, Yuqiang;  Yuan, Rong;  Chen, Keji;  Cong, Weihong;  Lee, Simon MingYuen
View  |  Adobe PDF(3018Kb)  |  Favorite  |  View/Download:354/13  |  Submit date:2018/10/30
Cardioprotection  Angiogenesis  ADTM  Zebrafish  VEGF