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MnSOD mediates shear stress-promoted tumor cell migration and adhesion Journal article
FREE RADICAL BIOLOGY AND MEDICINE, 2018,Volume: 129,Page: 46-58
Authors:  Ma, Shijun;  Fu, Afu;  Lim, Sierin;  Chiew, Geraldine Giap Ying;  Luo, Kathy Qian
Favorite  |  View/Download:1/0  |  Submit date:2019/01/17
Shear stress  Tumor cell adhesion  Tumor cell migration  Reactive oxygen species  MnSOD  FAK  
Inhibition of lung cancer by 2-methoxy-6-acetyl-7-methyljuglone (MAM) through induction of necroptosis by targeting receptor-interacting protein 1 (RIP1) Journal article
Antioxidants & Redox Signaling, 2018,Volume: 0,Issue: JA
Authors:  Sun W;  Yu J;  Gao H;  Wu X;  Wang S;  Hou Y;  Lu JJ;  Chen X
Favorite  |  View/Download:3/0  |  Submit date:2019/01/16
Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer Journal article
Cell Reports, 2018,Volume: 25,Issue: 8,Page: 2285-2298.e4
Authors:  Zhu D.;  Zhao Z.;  Cui G.;  Chang S.;  Hu L.;  See Y.X.;  Lim M.G.L.;  Guo D.;  Chen X.;  Robson P.;  Luo Y.;  Cheung E.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/17
Breast Cancer  Estrogen Receptor α  Metabolic Switch  Single-cell Rna Sequencing  
Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer Journal article
Advanced Biosystems, 2018,Issue: 1800241
Authors:  Ke Li;  Yunlu Dai;  Wen Chen;  Kang Yu;  Gao Xiao;  Joseph J. Richardson;  Wen Huang;  Junling Guo;  Xuepin Liao;  Bi Shi
Favorite  |  View/Download:2/0  |  Submit date:2019/01/28
Colon Cancer  Combination Therapy  Metal‐phenolic Networks  Rare Earth  Ros  
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:9/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:5/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Cyanidin-3-O-β-glucoside, a Natural Polyphenol, Exerts Proapoptotic Effects on Activated Platelets and Enhances Megakaryocytic Proplatelet Formation Journal article
Journal of Agricultural and Food Chemistry, 2018,Volume: 66,Issue: 41,Page: 10712-10720
Authors:  Ya F.;  Tian J.;  Li Q.;  Chen L.;  Ren J.;  Zhao Y.;  Wan J.;  Ling W.;  Yang Y.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/28
anthocyanins  cyanidin-3-O-β-glucoside  megakaryocyte  platelet apoptosis  proplatelet  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite  |  View/Download:8/0  |  Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Dihydronortanshinone, a natural product, alleviates LPS-induced inflammatory response through NF-κB, mitochondrial ROS, and MAPK pathways Journal article
Toxicology and Applied Pharmacology, 2018,Volume: 355,Page: 1-8
Authors:  Wu X.;  Gao H.;  Hou Y.;  Yu J.;  Sun W.;  Wang Y.;  Chen X.;  Feng Y.;  Xu Q.-M.;  Chen X.
Favorite  |  View/Download:5/0  |  Submit date:2018/12/28
Dihydronortanshinone  Inflammation  Lps  Macrophage