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Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships Journal article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018,Volume: 28,Issue: 21,Page: 3441-3445
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite | View/Download:20/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Antiproliferative activity  Dichloroacetophenone  Kinase inhibition  
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1 Journal article
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018,Volume: 123,Page: 43-55
Authors:  Zhang, Shao-Lin;  Yang, Zheng;  Hu, Xiaohui;  Chakravarty, Harapriya;  Tam, Kin Yip
Favorite | View/Download:27/0 | TC[WOS]:4 TC[Scopus]:0 | Submit date:2018/10/30
Dichloroacetophenone  Pyruvate Dehydrogenase Kinase  Pyruvate Dehydrogenase Complex  Anticancer Activity  Metabolic Reprogramming  
Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice Journal article
BIOORGANIC & MEDICINAL CHEMISTRY, 2018,Volume: 26,Issue: 18,Page: 5053-5061
Authors:  Chen, Shao-Ru;  Li, Feng;  Ding, Mo-Yu;  Wang, Decai;  Zhao, Qi;  Wang, Yitao;  Zhou, Guo-Chun;  Wang, Ying
View | Adobe PDF | Favorite | View/Download:1099/77 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/10/30
Andrographolide  Stat3 Inhibitor  Acute Liver Damage  Inflammation  
UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar Journal article
FRONTIERS IN PHARMACOLOGY, 2018,Volume: 9
Authors:  Xia, Fangbo;  Li, Ao;  Chai, Yushuang;  Xiao, Xiao;  Wan, Jianbo;  Li, Peng;  Wang, Yitao
View | Adobe PDF | Favorite | View/Download:549/29 | TC[WOS]:10 TC[Scopus]:0 | Submit date:2018/10/30
An-gong-niu-huang Wan  Cinnabar  Realgar  Metabonomics  Detoxification  Inflammation  
In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing Journal article
BIOMATERIALS, 2017,Volume: 148,Page: 54-68
Authors:  Li, Qiu;  Niu, Yiming;  Diao, Huajia;  Wang, Lintao;  Chen, Xiuping;  Wang, Yitao;  Dong, Lei;  Wang, Chunming
View | Adobe PDF | Favorite | View/Download:521/20 | TC[WOS]:29 TC[Scopus]:0 | Submit date:2018/10/30
Biomimetic Scaffolds  Extraceilular Matrix  Polysaccharides  Growth Factors  Wound Healing  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:514/10 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy Journal article
MOLECULAR PHARMACEUTICS, 2017,Volume: 14,Issue: 11,Page: 3644-3659
Authors:  Zhang, Jinming;  Zheng, Yifeng;  Xie, Xi;  Wang, Lan;  Su, Ziren;  Wang, Yitao;  Leong, Kam W.;  Chen, Meiwan
View | Adobe PDF | Favorite | View/Download:886/58 | TC[WOS]:12 TC[Scopus]:0 | Submit date:2018/10/30
Tumor-targeting  Glycyrrhetinic Acid  Ph-sensitive  Tat Exposure  Mixed Micelles  
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold Journal article
Bioorganic and Medicinal Chemistry, 2011,Volume: 19,Issue: 13,Page: 3906-3918
Authors:  Zhao A.;  Gao X.;  Wang Y.;  Ai J.;  Wang Y.;  Chen Y.;  Geng M.;  Zhang A.
Favorite | View/Download:6/0 | TC[WOS]:33 TC[Scopus]:0 | Submit date:2019/01/16
Antitumor  c-Met  Furo[2,3-d]pyrimidine  RTK  Thieno[2,3-d]pyrimidine  
Adiponectin, an Unlocking Adipocytokine Journal article
CARDIOVASCULAR THERAPEUTICS, 2009,Volume: 27,Issue: 1,Page: 59-75
Authors:  Sun, YY;  Xun, KL;  Wang, CG;  Zhao, HY;  Bi, HC;  Chen, XP;  Wang, YT
View | Adobe PDF | Favorite | View/Download:483/14 | TC[WOS]:57 TC[Scopus]:0 | Submit date:2018/11/01
Adiponecitn  Biomarker  Drug Target  Exercise  Gender Difference  Inflammation  
Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors Journal article
Bioorganic and Medicinal Chemistry Letters, 2006,Volume: 16,Issue: 6,Page: 1643-1646
Authors:  Smith II L.;  Piatnitski E.L.;  Kiselyov A.S.;  Ouyang X.;  Chen X.;  Burdzovic-Wizemann S.;  Xu Y.;  Wang Y.;  Rosler R.L.;  Patel S.N.;  Chiang H.-H.;  Milligan D.L.;  Columbus J.;  Wong W.C.;  Doody J.F.;  Hadari Y.R.
Favorite | View/Download:8/0 | TC[WOS]:18 TC[Scopus]:0 | Submit date:2019/01/16
Benzoxazepine  Epidermal growth factor receptor  Kinase inhibitor  Kinase selectivity