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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:331/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Sun,Xianding;  Zhou,Yang;  Zhang,Ruobin;  Wang,Zuqiang;  Xu,Meng;  Zhang,Dali;  Huang,Junlan;  Luo,Fengtao;  Li,Fangfang;  Ni,Zhenhong;  Zhou,Siru;  Chen,Hangang;  Chen,Shuai;  Chen,Liang;  Du,Xiaolan;  Chen,Bo;  Huang,Haiyang;  Liu,Peng;  Yin,Liangjun;  Qiu,Juhui;  Chen,Di;  Deng,Chuxia;  Xie,Yangli;  Luo,Lingfei;  Chen,Lin
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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite | View/Download:76/0 | TC[WOS]:0 TC[Scopus]:4 | Submit date:2020/09/16
BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis Journal article
Advanced Science, 2020,Volume: 7,Issue: 6
Authors:  Chen,Qiang;  Lei,Josh Haipeng;  Bao,Jiaolin;  Wang,Haitao;  Hao,Wenhui;  Li,Licen;  Peng,Cheng;  Masuda,Takaaki;  Miao,Kai;  Xu,Jun;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:79/0 | TC[WOS]:2 TC[Scopus]:8 | Submit date:2020/09/16
ATM-AMPK-DRP1  BRCA1  inflammasomes  mitochondrial dynamics  mitophagy  
FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice Journal article
Annals of the Rheumatic Diseases, 2020,Volume: 79,Issue: 1,Page: 112-122
Authors:  Kuang,Liang;  Wu,Jiangyi;  Su,Nan;  Qi,Huabing;  Chen,Hangang;  Zhou,Siru;  Xiong,Yan;  Du,Xiaolan;  Tan,Qiaoyan;  Yang,Jing;  Jin,Min;  Luo,Fengtao;  Ouyang,Junjie;  Zhang,Bin;  Wang,Zuqiang;  Jiang,Wanling;  Chen,Liang;  Chen,Shuai;  Wang,Ziming;  Liu,Peng;  Yin,Liangjun;  Guo,Fengjin;  Deng,Chuxia;  Chen,Di;  Liu,Chuanju;  Xie,Yangli;  Ni,Zhenhong;  Chen,Lin
Favorite | View/Download:80/0 | TC[WOS]:3 TC[Scopus]:5 | Submit date:2020/09/16
arthritis  chemokines  inflammation  synovitis  
Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulators Journal article
International Journal of Biological Sciences, 2020,Volume: 16,Issue: 8,Page: 1450-1462
Authors:  Zhong,Hui;  Ren,Zhili;  Wang,Xiaoyan;  Miao,Kai;  Ni,Wenjun;  Meng,Ya;  Lu,Ligong;  Wang,Chunming;  Liu,Weiwei;  Deng,Chu Xia;  Xu,Ren He;  Chen,Guokai
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Defined factors  Human embryonic stem cells  Keratinocyte differentiation  
Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling Journal article
Journal of Bone and Mineral Research, 2019,Volume: 34,Issue: 11,Page: 2101-2116
Authors:  Sun,Xianding;  Zhang,Ruobin;  Liu,Mi;  Chen,Hangang;  Chen,Liang;  Luo,Fengtao;  Zhang,Dali;  Huang,Junlan;  Li,Fangfang;  Ni,Zhenhong;  Qi,Huabing;  Su,Nan;  Jin,Min;  Yang,Jing;  Tan,Qiaoyan;  Du,Xiaolan;  Chen,Bo;  Huang,Haiyang;  Chen,Shuai;  Yin,Liangjun;  Xu,Xiaoling;  Deng,Chuxia;  Luo,Lingfei;  Xie,Yangli;  Chen,Lin
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CARTILAGE-HAIR HYPOPLASIA  RMRP  SKELETAL DEVELOPMENT  WNT/Β-CATENIN  ZEBRAFISH  
Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy Journal article
JOURNAL OF MATERIALS CHEMISTRY B, 2019
Authors:  Jingjing Wang;  Wei Sang;  Zhen Yang;  Zheyu Shen;  Zhantong Wang;  Orit Jacobson;  Yundai Chen;  Yong Wang;  Mingyan Shao;  Gang Niu,;  Yunlu Dai;  Xiaoyuan Chen
Favorite | View/Download:52/0 | TC[WOS]:0 TC[Scopus]:2 | Submit date:2020/05/12
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 10,Page: 1279-1291
Authors:  Lei Fan;  Xiao-xia Qiu;  Zhi-yuan Zhu;  Jian-lu Lv;  Jian Lu;  Fei Mao;  Jin Zhu;  Jia-ying Wang;  Xiao-wei Guan;  Jing Chen;  Jin Ren;  Ji-ming Ye;  Yong-hua Zhao;  Jian Li;  Xu Shen
Favorite | View/Download:23/0 | TC[WOS]:2 TC[Scopus]:8 | Submit date:2020/04/14
App/ps1 Transgenic Mice  Alzheimer’s Disease  Autophagy  Inflammation  Nitazoxanide  
Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma Journal article
BIOMATERIALS, 2019,Volume: 223
Authors:  Lijia Luo;  Muhammad Zubair Iqbal;  Chuang Liu;  Jie Xing;  Ozioma Udochukwu Akakuru;  Qianlan Fang;  Zihou Li;  Yunlu Dai;  Aiguo Li;  Yong Guan;  Aiguo Wu
Favorite | View/Download:96/0 | TC[WOS]:2 TC[Scopus]:12 | Submit date:2020/05/12
Cancer Immunotherapy  Nanomaterials  Prophylactic Vaccines  Metastasis  Dendritic Cells