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Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
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Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway Journal article
Cellular and Molecular Neurobiology, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu J.;  Zheng J.;  Lin J.;  Jin L.;  Yu R.;  Mak S.;  Hu S.;  Sun H.;  Wu X.;  Zhang Z.;  Lee M.;  Tsim W.;  Su W.;  Zhou W.;  Cui W.;  Han Y.;  Wang Q.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
ERK  GSK3β  H2O2  Indirubin-3-oxime  PI3-K  
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3 beta and the ERK Pathway Journal article
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017,Volume: 37,Issue: 4,Page: 655-664
Authors:  Yu, Jie;  Zheng, Jiacheng;  Lin, Jiajia;  Jin, Linlu;  Yu, Rui;  Mak, Shinghung;  Hu, Shengquan;  Sun, Hongya;  Wu, Xiang;  Zhang, Zaijun;  Lee, Mingyuen;  Tsim, Wahkeung;  Su, Wei;  Zhou, Wenhua;  Cui, Wei;  Han, Yifan;  Wang, Qinwen
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Indirubin-3-oxime  H2O2  GSK3 beta  PI3-K  ERK  
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β Journal article
Journal of Molecular Neuroscience, 2015,Volume: 57,Issue: 4,Page: 561
Authors:  Hu S.;  Cui W.;  Zhang Z.;  Mak S.;  Xu D.;  Li G.;  Hu Y.;  Wang Y.;  Lee M.;  Tsim K.W.;  Han Y.
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6OHDA  GSK3β  Indirubin-3-oxime  MEF2D  Neuroprotection  Parkinson’s disease  
New perspective on the dual functions of indirubins in cancer therapy and neuroprotection Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2014,Volume: 14,Issue: 9,Page: 1213-1219
Authors:  Wang Y.;  Hoi P.M.;  Chan J.Y.-W.;  Lee S.M.-Y.
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Cancer  Cdks  Dual Function  Gsk-3  Indirubin  Neurodegeneration  
Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model Journal article
Journal of Ethnopharmacology, 2010,Volume: 131,Issue: 2,Page: 242
Authors:  Alex D.;  Lam I.K.;  Lin Z.;  Lee S.M.Y.
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Anti-angiogenesis  Apoptosis  Indirubin  Zebrafish