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Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells Journal article
STEM CELLS, 2019,Volume: 37,Issue: 8,Page: 1030-1041
Authors:  Carlos Godoy‐Parejo;  Chunhao Deng;  Weiwei Liu;  Guokai Chen
Favorite  |  View/Download:10/0  |  Submit date:2020/05/21
Hesc  Cell Survival  Cell Adhesion  Focal Adhesion  Niche  Individualization  Insulin  Integrin  Caspase  Igf  Akt  
CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance Journal article
NANO LETTERS, 2019,Volume: 19,Issue: 5,Page: 3344-3352
Authors:  Xiajing Gu;  Yuanyuan Qiu;  Miao Lin;  Kai Cui;  Gaoxian Chen;  Yingzhi Chen;  Chenchen Fan;  Yongming Zhang;  Lu Xu;  Hongzhuan Chen;  Jian-Bo Wan;  Wei Lu;  Zeyu Xiao
Favorite  |  View/Download:9/0  |  Submit date:2020/04/22
Gefitinib  Cus Nanoparticles  Non-small Cell Lung Cancer  Rug Resistance  Active Oxygen Species  
Tanshinone IIA attenuates insulin like growth factor 1-induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways Journal article
International Journal of Molecular Sciences, 2018,Volume: 19,Issue: 9
Authors:  Wang H.;  Su X.;  Fang J.;  Xin X.;  Zhao X.;  Gaur U.;  Wen Q.;  Xu J.;  Little P.J.;  Zheng W.
Favorite  |  View/Download:17/0  |  Submit date:2018/12/21
Akt  Antiproliferation  ERK  IGF-1R  Tanshinone IIA  
Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway Journal article
BIOMEDICINE & PHARMACOTHERAPY, 2018,Volume: 101,Page: 334-341
Authors:  Wang, Anqi;  Wang, Shengpeng;  Zhou, Fayang;  Li, Peng;  Wang, Yitao;  Gan, Lishe;  Lin, Ligen
View  |  Adobe PDF(1614Kb)  |  Favorite  |  View/Download:371/19  |  Submit date:2018/10/30
Physalin b  Breast Cancer  Cell Cycle  Apoptosis  P53  Akt  
IGF-1-Mediated Survival from Induced Death of Human Primary Cultured Retinal Pigment Epithelial Cells Is Mediated by an Akt-Dependent Signaling Pathway Journal article
MOLECULAR NEUROBIOLOGY, 2018,Volume: 55,Issue: 3,Page: 1915-1927
Authors:  Zheng, Wenhua;  Meng, Qian;  Wang, Haitao;  Yan, Fengxia;  Little, Peter J.;  Deng, Xinguo;  Lin, Shaofen
Favorite  |  View/Download:23/0  |  Submit date:2018/10/30
Retinopathy  Serum Deprivation  Cell Signaling  Apoptosis  Growth Factors  
A dual-specific IGF-I/II human engineered antibody domain inhibits IGF signaling in breast cancer cells Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 7,Page: 799–806
Authors:  Zhizhen Chen;  Jie Liu;  Dafeng Chu;  Yaming Shan;  Guixing Ma;  Hongmin Zhang;  Xiaohua Douglas Zhang;  Pu Wang;  Qiang Chen;  Chuxia Deng;  Weizao Chen;  Dimiter Dimitrov;  Qi Zhao
Favorite  |  View/Download:10/0  |  Submit date:2018/12/17
Insulin-like Growth Factor  Yeast Display  Affinity Maturation  Ead  
Insulin-like growth factor-1 activates PI3K/Akt signalling to protect human retinal pigment epithelial cells from amiodarone-induced oxidative injury Journal article
BRITISH JOURNAL OF PHARMACOLOGY, 2018,Volume: 175,Issue: 1,Page: 125-139
Authors:  Liao, Rifang;  Yan, Fengxia;  Zeng, Zhuanping;  Wang, Haitao;  Qiu, Kaifeng;  Xu, Jinying;  Zheng, Wenhua
Favorite  |  View/Download:18/0  |  Submit date:2018/10/30
Amiodarone-Induced Retinal Neuronal Cell Apoptosis Attenuated by IGF-1 via Counter Regulation of the PI3k/Akt/FoxO3a Pathway Journal article
MOLECULAR NEUROBIOLOGY, 2017,Volume: 54,Issue: 9,Page: 6931-6943
Authors:  Liao, Rifang;  Yan, Fengxia;  Zeng, Zhuanping;  Farhan, Mohd;  Little, Peter;  Quirion, Remi;  Srivastava, Lalit K.;  Zheng, Wenhua
Favorite  |  View/Download:16/0  |  Submit date:2018/10/30
Amiodarone  Foxo3a  Akt  Antiarrhythmic  Apoptosis  Neuroprotection  
H2O2 attenuates IGF-1R tyrosine phosphorylation and its survival signaling properties in neuronal cells via NR2B containing NMDA receptor Journal article
ONCOTARGET, 2017,Volume: 8,Issue: 39,Page: 65313-65328
Authors:  Zeng, Zhiwen;  Wang, Dejun;  Gaur, Uma;  Liao Rifang;  Wang, Haitao;  Zheng, Wenhua
Favorite  |  View/Download:12/0  |  Submit date:2018/10/30
H2o2  Sh-sy5y  Nr2b  Nmda  Igf-1r  
Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017,Volume: 330,Page: 65-73
Authors:  Li, Ting;  Chen, Xin;  Dai, Xiao-Yang;  Wei, Bin;  Weng, Qin-Jie;  Chen, Xiuping;  Ouyang, De-Fang;  Yan, Ru;  Huang, Zhang-Jian;  Jiang, Hu-Lin;  Zhu, Hong;  Lu, Jin-Jian
Favorite  |  View/Download:16/0  |  Submit date:2018/10/30
Everolimus  Platycodin d  Hsp90  Cdc37  Egfr  Igf1r