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Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite | View/Download:73/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
The metabolic footprint during adipocyte commitment highlights ceramide modulation as an adequate approach for obesity treatment Journal article
EBioMedicine, 2020,Volume: 51
Authors:  Hou,Weilong;  Chen,Qiang;  Wang,Haitao;  Qiu,Pengxiang;  Lyu,Xueying;  Chen,Weiping;  Chua,Melvin L.K.;  Chinn,Y. Eugene;  Deng,Chu Xia;  Wang,Ruihong
Favorite | View/Download:73/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
Adipogenesis  Apoptosis  Ceramide  Epigenetic modification  Metabolic landscape  Metabolomics  Obesity  
TSA restores hair follicle-inductive capacity of skin-derived precursors Journal article
SCIENTIFIC REPORTS, 2019,Volume: 9
Authors:  Ling Guo;  Xiaoxiao Wang;  Jifan Yuan;  Meishu Zhu;  Xiaobing Fu;  Ren-He Xu;  Chuanyue Wu;  Yaojiong Wu
Favorite | View/Download:9/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2020/06/18
Requirements for RNA polymerase II preinitiation complex formation in vivo Journal article
ELIFE, 2019,Volume: 8
Authors:  Natalia Petrenko;  Yi Jin;  Liguo Dong;  Koon Ho Wong;  Kevin Struhl
Favorite | View/Download:10/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2020/06/12
γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis Journal article
Toxicology and Applied Pharmacology, 2019,Volume: 363,Page: 142-153
Authors:  Wang A.;  Zhou F.;  Li D.;  Lu J.-J.;  Wang Y.;  Lin L.
Favorite | View/Download:26/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2018/12/28
Fibrogenesis  Hmgb1  Liver Fibrosis  Sirtuin 3  Superoxide  Γ-mangostin  
gamma-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019,Volume: 363,Page: 142-153
Authors:  Wang A;  Zhou F;  Li D;  Lu JJ;  Wang Y;  Lin L
Favorite | View/Download:12/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2020/03/20
Superoxide  Gamma-mangostin  Fibrogenesis  Sirtuin 3  Liver Fibrosis  Hmgb1  
Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines Journal article
CANCERS, 2019,Volume: 11,Issue: 1
Authors:  Yang, GJ;  Ko, CN;  Zhong, HJ;  Leung, CH;  Ma, DL
Favorite | View/Download:12/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2020/03/24
Cell Cycle Arrest  Kdm5a  Jumonji Domain  Histone Demethylation  Protein-protein Interaction  Virtual Screening  Breast Cancer  Cell Senescence  
Pharmacological Inhibition of LSD1 for Cancer Treatment Journal article
MOLECULES, 2018,Volume: 23,Issue: 12
Authors:  Yang, Guan-Jun;  Lei, Pui-Man;  Wong, Suk-Yu;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite | View/Download:21/0 | TC[WOS]:17 TC[Scopus]:0 | Submit date:2019/01/17
Lsd1  Demethylase  Histone  Breast Cancer  Prostate Cancer  Acute Myeloid Leukemia  Cancer Therapy  
Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response Journal article
INORGANIC CHEMISTRY, 2018,Volume: 57,Issue: 22,Page: 14023-14026
Authors:  Kang, Tian-Shu;  Ko, Chung-Nga;  Zhang, Jia-Tong;  Wu, Chun;  Wong, Chun-Yuen;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite | View/Download:18/0 | TC[WOS]:3 TC[Scopus]:0 | Submit date:2019/01/17
Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy Journal article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018,Volume: 57,Issue: 40,Page: 13091-13095
Authors:  Yang, Guan-Jun;  Wang, Wanhe;  Mok, Simon Wing Fai;  Wu, Chun;  Law, Betty Yuen Kwan;  Miao, Xiang-Min;  Wu, Ke-Jia;  Zhong, Hai-Jing;  Wong, Chun-Yuen;  Wong, Vincent Kam Wai;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite | View/Download:44/0 | TC[WOS]:36 TC[Scopus]:0 | Submit date:2018/10/30
Drug Discovery  Epigenetics  Medicinal Chemistry  Triple-negative Breast Cancer