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The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism Journal article
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018,Volume: 37
Authors:  Feng, Yixiao;  Wu, Mingjun;  Li, Shuman;  He, Xiaoqian;  Tang, Jun;  Peng, Weiyan;  Zeng, Beilei;  Deng, Chuxia;  Ren, Guosheng;  Xiang, Tingxiu
Favorite  |  View/Download:1/0  |  Submit date:2019/01/17
CYGB  GLUT1  HXK2  p53  Breast cancer  Metabolism  Glycolysis  
Identification of Novel Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors by Kinase Activity-Based High-Throughput Screening for Anticancer Therapeutics Journal article
ACS Combinatorial Science, 2018,Volume: 20,Issue: 11,Page: 660-671
Authors:  Zhang W.;  Hu X.;  Chakravarty H.;  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:6/0  |  Submit date:2018/12/18
cancer  high-throughput screening  pyruvate dehydrogenase kinase 1  small molecule inhibitors  Warburg effect  
Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors Journal article
JOURNAL OF PROTEOME RESEARCH, 2018,Volume: 17,Issue: 9,Page: 3012-3021
Authors:  Zhang, Wen;  Hu, Xiaohui;  Zhou, Wei;  Tam, Kin Yip
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aerobic glycolysis  AZD7545  dichloroacetate  LC-MS/MS  pyruvate dehydrogenase kinases  cancer metabolism  
Targeting cancer metabolism to develop human lactate dehydrogenase (hLDH)5 inhibitors Journal article
DRUG DISCOVERY TODAY, 2018,Volume: 23,Issue: 7,Page: 1407-1415
Authors:  Zhang, Shao-Lin;  He, Yun;  Tam, Kin Yip
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The suppression of medium acidosis improves the maintenance and differentiation of human pluripotent stem cells at high density in defined cell culture medium Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 5,Page: 485-496
Authors:  Liu W.;  Ren Z.;  Lu K.;  Song C.;  Cheung E.C.W.;  Zhou Z.;  Chen G.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/17
Acidosis  Cell Death  Differentiation  Glycolysis  Human Pluripotent Stem Cells  
Molecular link between glucose and glutamine consumption in cancer cells mediated by CtBP and SIRT4 Journal article
ONCOGENESIS, 2018,Volume: 7
Authors:  Wang, Li;  Li, Jing-jiag;  Guo, Li-yu;  Li, Peipei;  Zhao, Zhiqiang;  Zhou, Haisheng;  Di, Li-jun
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The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 5,Page: 485-496
Authors:  Liu, Weiwei;  Ren, Zhili;  Lu, Kai;  Song, Chengcheng;  Cheung, Edwin Chong Wing;  Zhou, Zhou;  Chen, Guokai
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Human Pluripotent Stem Cells  Acidosis  Glycolysis  Cell Death  Differentiation  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 87-92
Authors:  Zhang S.-L.;  Zhang W.;  Yang Z.;  Hu X.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Anti-proliferation  Binding affinity  Pyruvate dehydrogenase complex  Pyruvate dehydrogenase kinase  
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells Conference paper
Authors:  Zhang, Shao-Lin;  Zhang, Wen;  Yang, Zheng;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:3/0  |  Submit date:2018/10/30
Pyruvate dehydrogenase kinase  Pyruvate dehydrogenase complex  Anti-proliferation  Binding affinity