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Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2018,Volume: 18,Issue: 4,Page: 550-555
Authors:  Tang Z.-H.;  Su M.-X.;  Guo X.;  Jiang X.-M.;  Jia L.;  Chen X.;  Lu J.-J.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/28
Azd9291  Egfr  Ire1α  Lune Cancer  Nsclc  Osimertinib  
Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 80-87
Authors:  Yang, Zheng;  Hu, Xiaohui;  Zhang, Shaolin;  Zhang, Wen;  Tam, Kin Yip
Favorite  |  View/Download:19/0  |  Submit date:2018/10/30
Synergism  Dichloroacetophenone  Dichloroacetate  Egfr  Apoptosis  Acquired Resistance  
Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol Journal article
International Journal of Oncology, 2016,Volume: 49,Issue: 4,Page: 1576-1588
Authors:  Xu S.-W.;  Law B.Y.K.;  Mok S.W.F.;  Leung E.L.H.;  Fan X.X.;  Coghi P.S.;  Zeng W.;  Leung C.-H.;  Ma D.-L.;  Liu L.;  Wong V.K.W.
Favorite  |  View/Download:4/0  |  Submit date:2018/11/06
Autophagy  Calcium  Celastrol  Epidermal growth factor receptor  Gefitinib-resistant lung cancer  
Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response Journal article
Journal of Pharmacy and Pharmacology, 2016,Volume: 68,Issue: 3,Page: 368-378
Authors:  Bernard R.;  Getachew R.;  Kamato D.;  Thach L.;  Osman N.;  Chan V.;  Zheng W.;  Little P.J.
Favorite  |  View/Download:1/0  |  Submit date:2018/12/21
cell signalling  GAG hyperelongation  platelet derived growth factor  proteoglycan  tinibs  transforming growth factor-β  
Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines Journal article
European Journal of Pharmacology, 2016,Volume: 789,Page: 458-467
Authors:  Yang Z.;  Tam K.Y.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/18
Dichloroacetate  Drug Combination  Epidermal Growth Factor Receptor  Erlotinib  Gefitinib  Pyruvate Dehydrogenase Kinase  
Characterization of osimertinib (AZD9291)-resistant non-small cell lung cancer NCI-H1975/OSIR cell line Journal article
Oncotarget, 2016,Volume: 7,Issue: 49,Page: 81598-81610
Authors:  Tang Z.-H.;  Jiang X.-M.;  Guo X.;  Fong C.M.V.;  Chen X.;  Lu J.-J.
Favorite  |  View/Download:5/0  |  Submit date:2018/12/28
Azd9291  Egfr  Navitoclax  Nsclc  Osimertinib  
Targeting the sheddase activity of Adam17 by an Anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 7,Page: 702-714
Authors:  Huang Y.;  Benaich N.;  Tape C.;  Kwok H.F.;  Murphy G.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/19
Adam17  Cell Proliferation And Motility  Her Receptor And ligAnds  Inhibitory Antibody  
Multi-Target Drugs: The Trend of Drug Research and Development Journal article
PLOS ONE, 2012,Volume: 7,Issue: 6,Page: 30-46
Authors:  Lu, JJ (Lu, Jin-Jian);  Pan, W (Pan, Wei);  Hu, YJ (Hu, Yuan-Jia);  Wang, YT (Wang, Yi-Tao
View  |  Adobe PDF(1050Kb)  |  Favorite  |  View/Download:84/3  |  Submit date:2018/11/01
Cancer-therapy  Alzheimers-disease  Parkinsons-disease  Attractive Target  Natural-products  b Inhibitors  Discovery  Atherosclerosis  Acetylcholinesterase  Proliferation  
Inhibitory activity of cetuximab on epidermal growth factor receptor mutations in non-small cell lung cancers Journal article
Molecular Cancer Therapeutics, 2007,Volume: 6,Issue: 10,Page: 2642-2651
Authors:  Doody J.F.;  Wang Y.;  Patel S.N.;  Joynes C.;  Sui P.L.;  Gerlak J.;  Rolser R.L.;  Li Y.;  Steiner P.;  Bassi R.;  Hicklin D.J.;  Hadari Y.R.
Favorite  |  View/Download:6/0  |  Submit date:2019/01/16