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Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 838,Page: 41-52
Authors:  Yang, Zheng;  Zhang, Shao-Lin;  Hu, Xiaohui;  Tam, Kin Yip
Favorite  |  View/Download:10/0  |  Submit date:2018/10/30
Dichloroacetophenone  Epidermal growth factor receptor  Tyrosine kinase inhibitor  Synergism  Hypoxia  Oxidative phosphorylation  
Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2018,Volume: 830,Page: 17-25
Authors:  Zhang, Le-Le;  Feng, Zhe-Ling;  Su, Min-Xia;  Jiang, Xiao-Ming;  Chen, Xiuping;  Wang, Yitao;  Li, Ao;  Lin, Li-Gen;  Lu, Jin-Jian
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Nagilactone e  Non-small Cell Lung Cancer  Cyclin B1  Cell Cycle  Apoptosis  
Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation Journal article
MOLECULES, 2018,Volume: 23,Issue: 7
Authors:  Li, Zhi-Peng;  Liu, Hong-Bing;  Zhang, Quan-Wei;  Li, Li-Feng;  Bao, Wan-Rong;  Ma, Dik-Lung;  Leung, Chung-Hang;  Bian, Zhao-Xiang;  Lu, Ai-Ping;  Han, Quan-Bin
View  |  Adobe PDF(1815Kb)  |  Favorite  |  View/Download:100/4  |  Submit date:2018/10/30
astragalus polysaccharide  quercetin  cytokines  macrophage  foods  
Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018,Volume: 14,Issue: 2,Page: 204-216
Authors:  Yang, Zheng;  Tam, Kin Yip
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Combination  Egfr-tki  Nsclc  Chemotherapy  Targeted Therapy  Immunotherapy  
Osimertinib resistance in non-small cell lung cancer: Mechanisms and therapeutic strategies Journal article
CANCER LETTERS, 2018,Volume: 420,Page: 242-246
Authors:  Tang, Zheng-Hai;  Lu, Jin-Jian
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Osimertinib  Azd9291  Egfr Tki  Resistant Mechanisms  Therapeutic Strategies  
Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells Journal article
Anti-Cancer Agents in Medicinal Chemistry, 2018,Volume: 18,Issue: 4,Page: 550-555
Authors:  Tang Z.-H.;  Su M.-X.;  Guo X.;  Jiang X.-M.;  Jia L.;  Chen X.;  Lu J.-J.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/28
Azd9291  Egfr  Ire1α  Lune Cancer  Nsclc  Osimertinib  
Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo Conference paper
Authors:  Ye, Jie;  Yuen, Shun Ming;  Murphy, Gillian;  Xie, Ruiyu;  Kwok, Hang Fai
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Pancreatic ductal adenocarcinoma (PDAC)  ADAM17  Inhibitory antibody  Tumorigenesis  Targeted therapy  
Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 62-69
Authors:  Ye J.;  Yuen S.M.;  Murphy G.;  Xie R.;  Kwok H.F.
Favorite  |  View/Download:2/0  |  Submit date:2018/12/19
Adam17  Inhibitory Antibody  Pancreatic Ductal Adenocarcinoma (Pdac)  Targeted Therapy  Tumorigenesis  
Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy Journal article
BIOMATERIALS, 2017,Volume: 148,Page: 69-80
Authors:  Chen, Qian;  Xu, Ligeng;  Chen, Jiawen;  Yang, Zhijuan;  Liang, Chao;  Yang, Yu;  Liu, Zhuang
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Erlotinib  Vascular normalization  Tumor microenvironment  Nanomedicine  Immunotherapy  
Pharmacological synergism of 2,2-dichloroacetophenone and EGFR-TKi to overcome TKi-induced resistance in NSCLC cells Journal article
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017,Volume: 815,Page: 80-87
Authors:  Yang, Zheng;  Hu, Xiaohui;  Zhang, Shaolin;  Zhang, Wen;  Tam, Kin Yip
Favorite  |  View/Download:8/0  |  Submit date:2018/10/30
Synergism  Dichloroacetophenone  Dichloroacetate  Egfr  Apoptosis  Acquired Resistance