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Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing Journal article
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018,Volume: 143,Page: 1021-1027
Authors:  Wu, Ke-Jia;  Zhong, Hai-Jing;  Li, Guodong;  Liu, Chenfu;  Wang, Hui-Min David;  Ma, Dik-Lung;  Leung, Chung-Hang
Favorite  |  View/Download:11/0  |  Submit date:2018/10/30
Drug repurposing  Mitoxantrone  NEDD8  Ubiquitin  
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer Journal article
British Journal of Pharmacology, 2014,Volume: 171,Issue: 19,Page: 4478-4489
Authors:  Wang M.;  Shim J.S.;  Li R.-J.;  Dang Y.;  He Q.;  Das M.;  Liu J.O.
Favorite  |  View/Download:3/0  |  Submit date:2019/01/15
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells Journal article
Breast Cancer Research, 2014,Volume: 16,Issue: 3
Authors:  Vazquez-Ortiz G.;  Chisholm C.;  Xu X.;  Lahusen T.J.;  Li C.;  Sakamuru S.;  Huang R.;  Thomas C.J.;  Xia M.;  Deng C.
Favorite  |  View/Download:7/0  |  Submit date:2018/12/13
Recent advances in drug repositioning for the discovery of new anticancer drugs Journal article
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2014,Volume: 10,Issue: 7,Page: 654-663
Authors:  Joong Sup Shim;  Jun O. Liu
Favorite  |  View/Download:1/0  |  Submit date:2019/01/24
Drug Repositioning  Drug Discovery  Cancer  Angiogenesis  Drug Screening  Drug Library  
Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer Journal article
Biochimie, 2011,Volume: 93,Issue: 6,Page: 1055-1064
Authors:  Chan D.S.-H.;  Yang H.;  Kwan M.H.-T.;  Cheng Z.;  Lee P.;  Bai L.-P.;  Jiang Z.-H.;  Wong C.-Y.;  Fong W.-F.;  Leung C.-H.;  Ma D.-L.
Favorite  |  View/Download:3/0  |  Submit date:2018/11/06
c-myc G-quadruplex  FDA-approved drug  Methylene blue  Repurposing  Structure-based optimization  
Structure-based repurposing of FDA-approved drugs as TNF-α inhibitors Journal article
ChemMedChem, 2011,Volume: 6,Issue: 5,Page: 765-768
Authors:  Leung C.-H.;  Chan D.S.-H.;  Kwan M.H.-T.;  Cheng Z.;  Wong C.-Y.;  Zhu G.-Y.;  Fong W.-F.;  Ma D.-L.
Favorite  |  View/Download:0/0  |  Submit date:2018/11/06
Approved drugs  Drug discovery  Inhibitors  Tumor necrosis factor  Virtual screening