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| Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells Journal article
Chinese Medicine (United Kingdom), 2021,Volume: 16,Issue: 1
Authors: Wang，Anqi; Liu，Jiayu; Yang，Yuhan; Chen，Zhejie; Gao，Caifang; Wang，Zhanguo; Fu，Chaomei; Zou，Liang; Wang，Shengpeng
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Apoptosis Breast cancer Necrosis Shikonin Ubiquitination |
| Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes Journal article
Journal of Hematology and Oncology, 2021,Volume: 14,Issue: 1
Authors: Liu，Jie; Yang，Shuo; Cao，Bihui; Zhou，Guangyu; Zhang，Fengjuan; Wang，Yuan; Wang，Rixin; Zhu，Lipeng; Meng，Ya; Hu，Cong; Liang，Hui; Lin，Xu; Zhu，Kangshun; Chen，Guokai; Luo，Kathy Qian; Di，Lijun; Zhao，Qi
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B7-H3 BiKE Bispecific antibody CAR T Chimeric antigen receptor Non-small cell lung cancer PD-L1 |
| Synthesis, biological evaluation and structure-activity relationship of novel dichloroacetophenones targeting pyruvate dehydrogenase kinases with potent anticancer activity Journal article
European Journal of Medicinal Chemistry, 2021,Volume: 214
Authors: Xu，Biao; Wang，Zhi Peng; Liu，Qingwang; Yang，Xiaohong; Li，Xuemin; Huang，Ding; Qiu，Yanfei; Tam，Kin Yip; Zhang，Shao Lin; He，Yun
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Cancer metabolism Proliferation Pyruvate dehydrogenase kinase Structure-activity relationship |
| Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy Journal article
Cell Reports, 2021,Volume: 34,Issue: 6
Authors: Han，Congwei; Song，Jinji; Hu，Junqing; Fu，Huijie; Feng，Yanxian; Mu，Ruoyu; Xing，Zhen; Wang，Zhenzhen; Wang，Lintao; Zhang，Junfeng; Wang，Chunming; Dong，Lei
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biofilm cancer therapy gut microbiome probiotics smectite |
| Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression Journal article
Oncogene, 2021,Volume: 40,Issue: 5,Page: 937-950
Authors: Shi，Changxiang; Yang，Eun Ju; Liu，Yifan; Mou，Pui Kei; Ren，Guowen; Shim，Joong Sup
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| Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes Journal article
Journal of Cellular Physiology, 2021,Volume: 236,Issue: 2,Page: 981-996
Authors: Peng，Cheng; Hou，Sheng Tao; Deng，Chu Xia; Zhang，Yandong
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demethylation DHX33 Gadd45a glycolysis RNA helicase Warburg effect |
| Polyphenol-Based Nanomedicine Evokes Immune Activation for Combination Cancer Treatment Journal article
Angewandte Chemie - International Edition, 2021,Volume: 60,Issue: 4,Page: 1967-1975
Authors: Zhang，Zhan; Sang，Wei; Xie，Lisi; Li，Wenxi; Li，Bei; Li，Jie; Tian，Hao; Yuan，Zhen; Zhao，Qi; Dai，Yunlu
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combination cancer therapy gossypol metal–polyphenol coordination nanomedicine PD-L1 checkpoint blockade |
| Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation Journal article
Oncogene, 2021,Volume: 40,Issue: 1,Page: 97-111
Authors: Zhang，Qingyu; Zhou，Wei; Yu，Shan; Ju，Yaojun; To，Sally Kit Yan; Wong，Alice Sze Tsai; Jiao，Yufei; Poon，Terence Chuen Wai; Tam，Kin Yip; Lee，Leo Tsz On
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| Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells Journal article
Phytomedicine, 2021,Volume: 80
Authors: Yuan，Luo Wei; Jiang，Xiao Ming; Xu，Yu Lian; Huang，Mu Yang; Chen，Yu Chi; Yu，Wei Bang; Su，Min Xia; Ye，Zi Han; Chen，Xiuping ; Wang，Yitao; Lu，Jin Jian
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IFN-γ Licochalcone A Natural products PD-L1 Protein synthesis inhibitor ROS |
| Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel Journal article
Theranostics, 2021,Volume: 11,Issue: 5,Page: 2442-2459
Authors: Wang，Haitao; Guo，Sen; Kim，Seung Jin; Shao，Fangyuan; Kei Ho，Joshua Wing; Wong，Kuan Un; Miao，Zhengqiang; Hao，Dapeng; Zhao，Ming; Xu，Jun; Zeng，Jianming; Wong，Koon Ho; Di，Lijun; Wong，Ada Hang Heng; Xu，Xiaoling; Deng，Chu Xia
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Cisplatin Metastasis Neoadjuvant therapy Paclitaxel TGFβ |
