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NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation Journal article
Nature Communications, 2020,Volume: 11,Issue: 1
Authors:  Miao,Kai;  Lei,Josh Haipeng;  Valecha,Monica Vishnu;  Zhang,Aiping;  Xu,Jun;  Wang,Lijian;  Lyu,Xueying;  Chen,Si;  Miao,Zhengqiang;  Zhang,Xin;  Su,Sek Man;  Shao,Fangyuan;  Rajendran,Barani Kumar;  Bao,Jiaolin;  Zeng,Jianming;  Sun,Heng;  Chen,Ping;  Tan,Kaeling;  Chen,Qiang;  Wong,Koon Ho;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:76/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/09/16
Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells Journal article
Acta Pharmaceutica Sinica B, 2020,Volume: 10,Issue: 4,Page: 615-627
Authors:  Zhang,Baoyuan;  Lyu,Junfang;  Yang,Eun Ju;  Liu,Yifan;  Wu,Changjie;  Pardeshi,Lakhansing;  Tan,Kaeling;  Chen,Qiang;  Xu,Xiaoling;  Deng,Chu Xia;  Shim,Joong Sup
Favorite | View/Download:73/0 | TC[WOS]:0 TC[Scopus]:1 | Submit date:2020/09/16
BRCA1  Breast cancer  DNA damage  HDAC  Histone deacetylase  Reactive oxygen species  Synthetic lethality  
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis Journal article
Advanced Science, 2020,Volume: 7,Issue: 6
Authors:  Chen,Qiang;  Lei,Josh Haipeng;  Bao,Jiaolin;  Wang,Haitao;  Hao,Wenhui;  Li,Licen;  Peng,Cheng;  Masuda,Takaaki;  Miao,Kai;  Xu,Jun;  Xu,Xiaoling;  Deng,Chu Xia
Favorite | View/Download:72/0 | TC[WOS]:2 TC[Scopus]:2 | Submit date:2020/09/16
ATM-AMPK-DRP1  BRCA1  inflammasomes  mitochondrial dynamics  mitophagy  
BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy Journal article
Human molecular genetics, 2018
Authors:  Xiaoling Xu;  Eric Chen;  Lihua Mo;  Lei Zhang;  Fangyuan Shao;  Kai Miao;  Jianlin Liu;  Sek Man Su;  Monica Valecha;  Un In Chan;  Hongping Zheng;  Mark Chen;  Weiping Chen;  Qiang Chen;  Haiqing Fu;  Mirit I. Aladjem;  Yanzhen He;  Chu-Xia Deng
Favorite | View/Download:42/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2018/12/17
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors Journal article
Experimental and Molecular Medicine, 2018,Volume: 50,Page: 136
Authors:  Choi, Eun Kyung;  Lim, Jeong-A;  Kim, Jong Kwang;  Jang, Moon Sun;  Kim, Sun Eui;  Baek, Hye Jung;  Park, Eun Jung;  Kim, Tae Hyun;  Deng, Chu-Xia;  Wang, Rui-Hong;  Kim, Sang Soo
Favorite | View/Download:36/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/10/30
Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 13,Page: 1769-1781
Authors:  Baek,Hye Jung;  Kim,Sun Eui;  Kim,Jong Kwang;  Shin,Dong Hoon;  Kim,Tae Hyun;  Kim,Kwang Gi;  Deng,Chu Xia;  Kim,Sang Soo
Favorite | View/Download:70/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2020/09/16
AKT  BRCA1  MK-2206  Precision medicine  
Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors Journal article
Experimental and Molecular Medicine, 2018,Volume: 50,Issue: 10
Authors:  Choi,Eun Kyung;  Lim,Jeong A.;  Kim,Jong Kwang;  Jang,Moon Sun;  Kim,Sun Eui;  Baek,Hye Jung;  Park,Eun Jung;  Kim,Tae Hyun;  Deng,Chu Xia;  Wang,Rui Hong;  Kim,Sang Soo
Favorite | View/Download:71/0 | TC[WOS]:3 TC[Scopus]:3 | Submit date:2020/09/16
Inhibition of estrogen signaling reduces the incidence of BRCA1-associated mammary tumor formation Journal article
International Journal of Biological Sciences, 2018,Volume: 14,Issue: 12,Page: 1755-1768
Authors:  Baek,Hye Jung;  Kim,Sun Eui;  Choi,Eun Kyung;  Kim,Jong Kwang;  Shin,Dong Hoon;  Park,Eun Jung;  Kim,Tae Hyun;  Kim,Joo Young;  Kim,Kwang Gi;  Deng,Chu Xia;  Kim,Sang Soo
Favorite | View/Download:4/0 | TC[WOS]:2 TC[Scopus]:2 | Submit date:2020/09/16
BRCA1  Cancer prevention  Estrogen  Fulvestrant  
Immunogenomic analyses of advanced serous ovarian cancer reveal immune score is a strong prognostic factor and an indicator of chemosensitivity Journal article
Clinical Cancer Research, 2018,Volume: 24,Issue: 15,Page: 3560-3571
Authors:  Hao D.;  Liu J.;  Chen M.;  Li J.;  Wang L.;  Li X.;  Zhao Q.;  Di L.-J.
Favorite | View/Download:8/0 | TC[WOS]:7 TC[Scopus]:0 | Submit date:2018/12/21
BRCA1 deficiency sensitizes breast cancer cells to bromodomain and extra-terminal domain (BET) inhibition Journal article
Oncogene, 2018,Issue: 37,Page: 6341–6356
Authors:  Baoyuan Zhang;  Junfang Lyu;  Yifan Liu;  Changjie Wu;  Eun Ju Yang;  Lakhansing Pardeshi;  Kaeling Tan;  Koon Ho Wong;  Qiang Chen;  Xiaoling Xu;  Chu-Xia Deng;  Joong Sup Shim
Favorite | View/Download:27/0 | TC[WOS]:2 TC[Scopus]:0 | Submit date:2018/12/17