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Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 350,Page: 32-42
Authors:  Zhou, Zhong-Yan;  Huang, Bin;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Kwan, Yiu Wa;  Hoi, Pui Man;  Lee, Simon Ming-Yuen
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Sodium tanshinone IIA sulfonate  Salvia miltiorrhiza  Hemorrhagic stroke  Atorvastatin  ROCK  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell–cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility Journal article
Pharmacological Research, 2018,Volume: 128,Page: 389-398
Authors:  Huang B.;  Zhou Z.-Y.;  Li S.;  Huang X.-H.;  Tang J.-Y.;  Hoi M.P.M.;  Lee S.M.Y.
Favorite  |  View/Download:2/0  |  Submit date:2018/11/06
Endothelial cell adhesion  Hemorrhagic stroke  HUVECs  Tanshinone I  Vascular integrity  Zebrafish  
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting. VE-cadherin internalization and actin-myosin contractility Journal article
PHARMACOLOGICAL RESEARCH, 2018,Volume: 128,Page: 389-398
Authors:  Huang, Bin;  Zhou, Zhong-Yan;  Li, Shang;  Huang, Xiao-Hui;  Tang, Jing-Yi;  Hoi, Maggie Pui Man;  Lee, Simon Ming Yuen
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Tanshinone I  Vascular integrity  Endothelial cell adhesion  Hemorrhagic stroke  Zebrafish  HUVECs  
Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia Journal article
PHYTOTHERAPY RESEARCH, 2017,Volume: 31,Issue: 10,Page: 1579-1589
Authors:  Cheung, David Wing-Shing;  Koon, Chi-Man;  Wong, Pui-Han;  Yau, Ka-Chun;  Wat, Elaine;  Hung, Angela Sze-Man;  Wang, Yan-Ping;  Lau, Kit-Man;  Ko, Chun-Hay;  Chan, Judy Yuet-Wa;  Waye, Mary Miu-Yee;  Fung, Kwok-Pui
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hyperlipidemia  herbal medicine  Danshen  Gegen  atorvastatin  herb-drug interaction  
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays Journal article
Scientific Reports, 2015,Volume: 5
Authors:  Shen M.;  Tian S.;  Pan P.;  Sun H.;  Li D.;  Li Y.;  Zhou H.;  Li C.;  Lee S.M.-Y.;  Hou T.
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Discovery of Rho-kinase inhibitors by docking-based virtual screening Journal article
Molecular BioSystems, 2013,Volume: 9,Issue: 6,Page: 1511
Authors:  Shen M.;  Yu H.;  Li Y.;  Li P.;  Pan P.;  Zhou S.;  Zhang L.;  Li S.;  Lee S.M.-Y.;  Hou T.
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TNF-alpha, a potent lipid metabolism regulator Journal article
CELL BIOCHEMISTRY AND FUNCTION, 2009,Volume: 27,Issue: 7,Page: 407-416
Authors:  Chen, XP;  Xun, KL;  Chen, LD;  Wang, YT
View  |  Adobe PDF(231Kb)  |  Favorite  |  View/Download:96/3  |  Submit date:2018/11/01
Tumor Necrosis Factor Alpha  Free Fatty Acid  Lipolysis  Cholesterol  Leptin  Adiponectin  Infliximab  
Statins and PPARα agonists induce myotoxicity in differentiated rat skeletal muscle cultures but do not exhibit synergy with co-treatment Journal article
Toxicology and Applied Pharmacology, 2005,Volume: 208,Issue: 3,Page: 210-221
Authors:  Johnson T.E.;  Zhang X.;  Shi S.;  Umbenhauer D.R.
Favorite  |  View/Download:2/0  |  Submit date:2019/01/03
Co-treatment  Myopathy  Myotoxicity  Statin PPAR  Synergy