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Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice Journal article
ACTA PHARMACOLOGICA SINICA, 2019,Volume: 40,Issue: 9,Page: 1193-1204
Authors:  Ting-ting Zhou;  Tong Zhao;  Fei Ma;  Yi-nan Zhang;  Jing Jiang;  Yuan Ruan;  Qiu-ying Yan;  Gai-hong Wang;  Jin Ren;  Xiao-wei Guan;  Jun Guo;  Yong-hua Zhao;  Ji-ming Ye;  Li-hong Hu;  Jing Chen;  Xu Shen
Favorite  |  View/Download:5/0  |  Submit date:2020/04/14
Type 2 Diabetes Mellitus  Hepatic Gluconeogenesis  Ampk Signaling Pathway  (e)-3-(2-(Quinoline-4-yl)Vinyl)-1h-indol-6-ol (Qvo)  4-[2-(1h-indol-3-yl)Vinyl]Quinoline (Ivq)  Prodrug  
Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells Journal article
STEM CELL REPORTS, 2019,Volume: 13,Issue: 2,Page: 338-351
Authors:  Chengcheng Song;  Faxiang Xu;  Zhili Ren;  Yumeng Zhang;  Ya Meng;  Yiqi Yang;  Shreyas Lingadahalli;  Edwin Cheung;  Gang Li;  Weiwei Liu;  Jianbo Wan;  Yang Zhao;  Guokai Chen
Favorite  |  View/Download:12/0  |  Submit date:2020/04/22
Hescs  Pyruvate  Bmp4  Glycolysis  Tca Cycle  Ampk  Wnt  Metabolism  Mesoderm  Differentiation  
A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice Journal article
PHYTOMEDICINE, 2019,Volume: 58
Authors:  Feng Ruibing;  Chen Jie-Hua;  Liu Cong-Hui;  Xia Fang-Bo;  Xiao Zeyu;  hang Xuguang;  Wan Jian-Bo
Favorite  |  View/Download:10/0  |  Submit date:2020/04/22
SiL.bum Marianum(L.)Gaerth  Pueraria Lobata(Wild.)Ohwi  Alcoholic Liver Disease  Hepatic Inflammation  Intestinal Barrier Dysfunction  
Upregulation of phosphoserine phosphatase contributes to tumor progression and predicts poor prognosis in non-small cell lung cancer patients Journal article
THORACIC CANCER, 2019,Volume: 10,Issue: 5,Page: 1203-1212
Authors:  Li Liao;  Huajian Yu;  Mengxi Ge;  Qiong Zhan;  Ruofan Huang;  Xiaoyu Ji;  Xiaohua Liang;  Xinli Zhou
Favorite  |  View/Download:9/0  |  Submit date:2020/03/10
Akt/ampk Signaling Pathway  Metastasis  Nsclc  Proliferation  Psph  
Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase Journal article
Food Chemistry, 2019,Volume: 270,Page: 305-314
Authors:  Shen S.;  Liao Q.;  Feng Y.;  Liu J.;  Pan R.;  Lee S.M.-Y.;  Lin L.
Favorite  |  View/Download:20/0  |  Submit date:2018/11/06
Adipogenesis  Amp-activated Protein Kinase  Insulin Sensitivity  Lipid Accumulation  Myricanol  Zebrafish  
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling Journal article
ENDOCRINE-RELATED CANCER, 2018,Volume: 25,Issue: 4,Page: 453-469
Authors:  White, Mark A.;  Tsouko, Efrosini;  Lin, Chenchu;  Rajapakshe, Kimal;  Spencer, Jeffrey M.;  Wilkenfeld, Sandi R.;  Vakili, Sheiva S.;  Pulliam, Thomas L.;  Awad, Dominik;  Nikolos, Fotis;  Katreddy, Rajasekhara Reddy;  Kaipparettu, Benny Abraham;  Sreekumar, Arun;  Zhang, Xiaoliu;  Cheung, Edwin;  Coarfa, Cristian;  Frigo, Daniel E.
Favorite  |  View/Download:13/0  |  Submit date:2018/10/30
GLUT12  SLC2A12  glucose metabolism  androgen receptor (AR)  calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)  5 '-AMP-activated protein kinase (AMPK)  prostate cancer  
Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3-TGF-beta-Smad signaling pathway Journal article
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018,Volume: 341,Page: 38-50
Authors:  Zhou, Fayang;  Wang, Anqi;  Li, Dan;  Wang, Yitao;  Lin, Ligen
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Liver Fibrosis  Hepatic Stellate Cells  Penthorum Chinense Pursh  Pinocembrin  Sma- And Mad-related Proteins  Silent Mating Type Information Regulation 2 Homolog 3  
gamma-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction Journal article
JOURNAL OF FUNCTIONAL FOODS, 2018,Volume: 40,Page: 544-553
Authors:  Wang, Anqi;  Li, Dan;  Wang, Shengpeng;  Zhou, Fayang;  Li, Peng;  Wang, Yitao;  Lin, Ligen
View  |  Adobe PDF(1410Kb)  |  Favorite  |  View/Download:373/19  |  Submit date:2018/10/30
Gamma-mangostin  Mangosteen  Liver Oxidative Injury  Nrf2  Sirt1  Pgc-1 Alpha  
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways Journal article
SCIENTIFIC REPORTS, 2017,Volume: 7
Authors:  Zhang, Chao;  Li, Chuwen;  Chen, Shenghui;  Li, Zhiping;  Ma, Lijuan;  Jia, Xuejing;  Wang, Kai;  Bao, Jiaolin;  Liang, Yeer;  Chen, Meiwan;  Li, Peng;  Su, Huanxing;  Lee, Simon Ming Yuen;  Liu, Kechun;  Wan, Jian-Bo;  He, Chengwei
Favorite  |  View/Download:22/0  |  Submit date:2018/10/30
Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of MTOR signaling and angiogenesis Journal article
ACS Chemical Biology, 2017,Volume: 12,Issue: 1,Page: 174
Authors:  Head S.A.;  Shi W.Q.;  Yang E.J.;  Nacev B.A.;  Hong S.Y.;  Pasunooti K.K.;  Li R.-J.;  Shim J.S.;  Liu J.O.
Favorite  |  View/Download:6/0  |  Submit date:2018/10/30