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Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology Journal article
FRONTIERS IN PHARMACOLOGY, 2019
Authors:  Ning-Ning Yuan;  Cui-Zan Cai;  Ming-Yue Wu;  Qi Zhu;  HuanXing Su;  Min Li;  JiaoYan Ren;  Jie-Qiong Tan;  Jia-Hong Lu
Favorite | View/Download:29/0 | TC[WOS]:3 TC[Scopus]:5 | Submit date:2020/04/14
Canthin-6-one  Parkinson’s Disease  Alpha-synuclein  Ubiquitin-proteasome-system  Crispr/cas9  Rpn2/psmd1  Pka  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:521/10 | TC[WOS]:7 TC[Scopus]:12 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Journal article
CELL DEATH & DISEASE, 2017,Volume: 8
Authors:  Zou, Jing;  Chen, Zhaoyu;  Wei, Xiaobo;  Chen, Zhigang;  Fu, Yongmei;  Yang, Xiaoyan;  Chen, Dan;  Wang, Rui;  Jenner, Peter;  Lu, Jia-Hong;  Li, Min;  Zhang, Zhuohua;  Tang, Beisha;  Jin, Kunlin;  Wang, Qing
Favorite | View/Download:16/0 | TC[WOS]:42 TC[Scopus]:48 | Submit date:2018/10/31
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Journal article
CELL DEATH & DISEASE, 2017,Volume: 8
Authors:  Zou, Jing;  Chen, Zhaoyu;  Wei, Xiaobo;  Chen, Zhigang;  Fu, Yongmei;  Yang, Xiaoyan;  Chen, Dan;  Wang, Rui;  Jenner, Peter;  Lu, Jia-Hong;  Li, Min;  Zhang, Zhuohua;  Tang, Beisha;  Jin, Kunlin;  Wang, Qing
Favorite | View/Download:17/0 | TC[WOS]:42 TC[Scopus]:48 | Submit date:2018/10/31
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Journal article
CELL DEATH & DISEASE, 2017,Volume: 8
Authors:  Zou, Jing;  Chen, Zhaoyu;  Wei, Xiaobo;  Chen, Zhigang;  Fu, Yongmei;  Yang, Xiaoyan;  Chen, Dan;  Wang, Rui;  Jenner, Peter;  Lu, Jia-Hong;  Li, Min;  Zhang, Zhuohua;  Tang, Beisha;  Jin, Kunlin;  Wang, Qing
Favorite | View/Download:27/0 | TC[WOS]:42 TC[Scopus]:48 | Submit date:2018/10/30
Cystatin C as a potential therapeutic mediator against Parkinson's disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units Journal article
CELL DEATH & DISEASE, 2017,Volume: 8
Authors:  Zou, Jing;  Chen, Zhaoyu;  Wei, Xiaobo;  Chen, Zhigang;  Fu, Yongmei;  Yang, Xiaoyan;  Chen, Dan;  Wang, Rui;  Jenner, Peter;  Lu, Jia-Hong;  Li, Min;  Zhang, Zhuohua;  Tang, Beisha;  Jin, Kunlin;  Wang, Qing
Favorite | View/Download:12/0 | TC[WOS]:42 TC[Scopus]:48 | Submit date:2018/10/30
Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy Journal article
AUTOPHAGY, 2017,Volume: 13,Issue: 11,Page: 1969-1980
Authors:  Chen, Lei-Lei;  Wang, Yong-Bo;  Song, Ju-Xian;  Deng, Wan-Kun;  Lu, Jia-Hong;  Ma, Li-Li;  Yang, Chuan-Bin;  Li, Min;  Xue, Yu
Favorite | View/Download:30/0 | TC[WOS]:10 TC[Scopus]:13 | Submit date:2018/10/30
Autophagy  Corynoxine  Kinase Activity  Phosphoproteome  Phosphorylation  Protein Kinase  
Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson's Disease Models Journal article
Antioxidants and Redox Signaling, 2016,Volume: 25,Issue: 8,Page: 485-497
Authors:  Lehtonen S.;  Jaronen M.;  Vehvilainen P.;  Lakso M.;  Rudgalvyte M.;  Keksa-Goldsteine V.;  Wong G.;  Courtney M.J.;  Koistinaho J.;  Goldsteins G.
Favorite | View/Download:8/0 | TC[WOS]:9 TC[Scopus]:5 | Submit date:2018/12/18
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease Journal article
Scientific Reports, 2015,Volume: 5
Authors:  Liu L.-F.;  Song J.-X.;  Lu J.-H.;  Huang Y.-Y.;  Zeng Y.;  Chen L.-L.;  Durairajan S.S.K.;  Han Q.-B.;  Li M.
Favorite | View/Download:10/0 | TC[WOS]:22 TC[Scopus]:26 | Submit date:2019/01/15
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils Journal article
Neurobiology of Disease, 2015,Volume: 74,Page: 89
Authors:  Ardah M.T.;  Paleologou K.E.;  Lv G.;  Menon S.A.;  Abul Khair S.B.;  Lu J.-H.;  Safieh-Garabedian B.;  Al-Hayani A.A.;  Eliezer D.;  Li M.;  El-Agnaf O.M.A.
Favorite | View/Download:14/0 | TC[WOS]:47 TC[Scopus]:48 | Submit date:2018/10/30
Aggregation  Amyloid Fibrils  Drug Discovery  Ginsenosides  Parkinson's Disease  Α-synuclein