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Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo Conference paper
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Zhuhai, PEOPLES R CHINA, AUG 23-26, 2016
Authors:  Ye, Jie;  Yuen, Shun Ming;  Murphy, Gillian;  Xie, Ruiyu;  Kwok, Hang Fai
Favorite | View/Download:19/0 | TC[WOS]:6 TC[Scopus]:7 | Submit date:2018/10/31
Pancreatic Ductal Adenocarcinoma (Pdac)  Adam17  Inhibitory Antibody  Tumorigenesis  Targeted Therapy  
Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 62-69
Authors:  Ye J.;  Yuen S.M.;  Murphy G.;  Xie R.;  Kwok H.F.
Favorite | View/Download:13/0 | TC[WOS]:6 TC[Scopus]:7 | Submit date:2018/12/19
Adam17  Inhibitory Antibody  Pancreatic Ductal Adenocarcinoma (Pdac)  Targeted Therapy  Tumorigenesis  
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm Journal article
Hypertension, 2017,Volume: 70,Issue: 5,Page: 959-963
Authors:  Kawai T.;  Takayanagi T.;  Forrester S.J.;  Preston K.J.;  Obama T.;  Tsuji T.;  Kobayashi T.;  Boyer M.J.;  Cooper H.A.;  Kwok H.F.;  Hashimoto T.;  Scalia R.;  Rizzo V.;  Eguchi S.
Favorite | View/Download:10/0 | TC[WOS]:11 TC[Scopus]:18 | Submit date:2018/12/19
Aneurysm  Angiotensin Ii  Hypertension  Rupture  Signal Transduction  
Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II Journal article
Hypertension, 2016,Volume: 68,Issue: 4,Page: 949-955
Authors:  Takayanagi T.;  Forrester S.J.;  Kawai T.;  Obama T.;  Tsuji T.;  Elliott K.J.;  Nuti E.;  Rossello A.;  Kwok H.F.;  Scalia R.;  Rizzo V.;  Eguchi S.
Favorite | View/Download:18/0 | TC[WOS]:27 TC[Scopus]:32 | Submit date:2018/12/19
End-organ Damage  Fibrosis  Hypertension  Renin Angiotensin System  Signal Transduction  
Targeting the sheddase activity of Adam17 by an Anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 7,Page: 702-714
Authors:  Huang Y.;  Benaich N.;  Tape C.;  Kwok H.F.;  Murphy G.
Favorite | View/Download:9/0 | TC[WOS]:21 TC[Scopus]:27 | Submit date:2018/12/19
Adam17  Cell Proliferation And Motility  Her Receptor And ligAnds  Inhibitory Antibody  
Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy Journal article
Protein Engineering, Design and Selection, 2014,Volume: 27,Issue: 6,Page: 179-190
Authors:  Kwok H.F.;  Botkjaer K.A.;  Tape C.J.;  Huang Y.;  McCafferty J.;  Murphy G.
Favorite | View/Download:9/0 | TC[WOS]:20 TC[Scopus]:21 | Submit date:2018/12/19
Anti-tace Antibody  Exosite  Immunoreactivity  Phage-display Randomization Libraries  Sub-nanomolar Affinity  
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin Journal article
HUMAN MOLECULAR GENETICS, 2014,Volume: 23,Issue: 4,Page: 929-941
Authors:  van 't Wout, EF;  Dickens, JA;  van Schadewijk, A;  Haq, I;  Kwok, HF;  Ordonez, A;  Murphy, G;  Stolk, J;  Lomas, DA;  Hiemstra, PS;  Marciniak, SJ
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USE OF ANTI-TUMOUR EFFECTS OF A ' HUMAN & MOUSE CROSS-REACTIVE' ANTI-ADAM17 ANTIBODY IN TREATING PANCREATIC CANCER Patent
专利类型: 发明专利, 专利号: US20190375848A1, 申请日期: 2018-07-12, 公开日期: 2019-12-12
Authors:  Hang Fai KWOK;  Ruiyu XIE
Favorite | View/Download:4/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/05/27
Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II Patent
专利类型: 发明专利, 专利号: US20190015505A1, 申请日期: 2018-07-11, 公开日期: 2019-01-17
Authors:  Hang Fai KWOK
Favorite | View/Download:6/0 | TC[WOS]:0 TC[Scopus]:0 | Submit date:2020/05/27