UM

Browse/Search Results:  1-7 of 7 Help

Selected(0)Clear Items/Page:    Sort:
Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo Conference paper
Authors:  Ye, Jie;  Yuen, Shun Ming;  Murphy, Gillian;  Xie, Ruiyu;  Kwok, Hang Fai
Favorite  |  View/Download:5/0  |  Submit date:2018/10/31
Pancreatic ductal adenocarcinoma (PDAC)  ADAM17  Inhibitory antibody  Tumorigenesis  Targeted therapy  
Anti-tumor effects of a ‘human & mouse cross-reactive’ anti-ADAM17 antibody in a pancreatic cancer model in vivo Journal article
European Journal of Pharmaceutical Sciences, 2017,Volume: 110,Page: 62-69
Authors:  Ye J.;  Yuen S.M.;  Murphy G.;  Xie R.;  Kwok H.F.
Favorite  |  View/Download:2/0  |  Submit date:2018/12/19
Adam17  Inhibitory Antibody  Pancreatic Ductal Adenocarcinoma (Pdac)  Targeted Therapy  Tumorigenesis  
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/β-Aminopropionitrile-Induced Abdominal Aortic Aneurysm Journal article
Hypertension, 2017,Volume: 70,Issue: 5,Page: 959-963
Authors:  Kawai T.;  Takayanagi T.;  Forrester S.J.;  Preston K.J.;  Obama T.;  Tsuji T.;  Kobayashi T.;  Boyer M.J.;  Cooper H.A.;  Kwok H.F.;  Hashimoto T.;  Scalia R.;  Rizzo V.;  Eguchi S.
Favorite  |  View/Download:2/0  |  Submit date:2018/12/19
Aneurysm  Angiotensin Ii  Hypertension  Rupture  Signal Transduction  
Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II Journal article
Hypertension, 2016,Volume: 68,Issue: 4,Page: 949-955
Authors:  Takayanagi T.;  Forrester S.J.;  Kawai T.;  Obama T.;  Tsuji T.;  Elliott K.J.;  Nuti E.;  Rossello A.;  Kwok H.F.;  Scalia R.;  Rizzo V.;  Eguchi S.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/19
End-organ Damage  Fibrosis  Hypertension  Renin Angiotensin System  Signal Transduction  
Targeting the sheddase activity of Adam17 by an Anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation Journal article
International Journal of Biological Sciences, 2014,Volume: 10,Issue: 7,Page: 702-714
Authors:  Huang Y.;  Benaich N.;  Tape C.;  Kwok H.F.;  Murphy G.
Favorite  |  View/Download:4/0  |  Submit date:2018/12/19
Adam17  Cell Proliferation And Motility  Her Receptor And ligAnds  Inhibitory Antibody  
Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy Journal article
Protein Engineering, Design and Selection, 2014,Volume: 27,Issue: 6,Page: 179-190
Authors:  Kwok H.F.;  Botkjaer K.A.;  Tape C.J.;  Huang Y.;  McCafferty J.;  Murphy G.
Favorite  |  View/Download:3/0  |  Submit date:2018/12/19
Anti-tace Antibody  Exosite  Immunoreactivity  Phage-display Randomization Libraries  Sub-nanomolar Affinity  
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin Journal article
HUMAN MOLECULAR GENETICS, 2014,Volume: 23,Issue: 4,Page: 929-941
Authors:  van 't Wout, EF;  Dickens, JA;  van Schadewijk, A;  Haq, I;  Kwok, HF;  Ordonez, A;  Murphy, G;  Stolk, J;  Lomas, DA;  Hiemstra, PS;  Marciniak, SJ
Favorite  |  View/Download:1/0  |  Submit date:2019/01/10