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Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson’s Disease Journal article
AGING AND DISEASE, 2019,Volume: 10,Issue: 5,Page: 1037-1048
Authors:  Yuan Tan;  Minjing Ke;  Zhijian Huang;  Cheong-Meng Chong;  Xiaotong Cen;  Jia-Hong Lu;  Xiaoli Yao;  Dajiang Qin;  Huanxing Su
Favorite | View/Download:24/0 | TC[WOS]:2 TC[Scopus]:4 | Submit date:2020/04/08
Disease Phenotypes  Er Stress  Induced Pluripotentstem Cells  Parkinson’s Disease  Hydroxyurea  
N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF Journal article
MOLECULAR NEUROBIOLOGY, 2018,Volume: 55,Issue: 3,Page: 2258-2267
Authors:  Luo, Dan;  Zhao, Jia;  Cheng, Yuanyuan;  Lee, Simon Ming-Yuen;  Rong, Jianhui
Favorite | View/Download:14/0 | TC[WOS]:8 TC[Scopus]:15 | Submit date:2018/10/31
Parkinson's disease  Neuroprotection  N-propargyl caffeamide (PACA)  NGF/TrkApathway  PI3K/Akt  ERK1/2  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:521/10 | TC[WOS]:7 TC[Scopus]:12 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders Journal article
CURRENT DRUG TARGETS, 2017,Volume: 18,Issue: 4,Page: 455-462
Authors:  Chong, Cheong-Meng;  Ai, Nana;  Lee, Simon Ming-Yuen
Favorite | View/Download:35/0 | TC[WOS]:14 TC[Scopus]:17 | Submit date:2018/10/30
Axonal Regeneration  Central Nervous System  Fasudil  Isoforms  Limk  Neurodegenerative Diseases  Rock  
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models Journal article
Neurochemistry International, 2016,Volume: 99,Page: 194-205
Authors:  Xu D.;  Chen H.;  Mak S.;  Hu S.;  Tsim K.W.K.;  Hu Y.;  Sun Y.;  Zhang G.;  Wang Y.;  Zhang Z.;  Han Y.
Favorite | View/Download:12/0 | TC[WOS]:9 TC[Scopus]:13 | Submit date:2018/12/28
Alzheimer's Disease  Excitotoxicity  Neurite Outgrowth  Neuroprotection  Tetramethylpyrazine Derivative  
Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening Journal article
Molecular BioSystems, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:13/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/11/06
A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro Journal article
Molecular and Cellular Neuroscience, 2016,Volume: 71,Page: 80-91
Authors:  Sun Z.;  Dai X.;  Li Y.;  Jiang S.;  Lou G.;  Cao Q.;  Hu R.;  Huang Y.;  Su Z.;  Chen M.;  Luo H.;  Lin X.;  Sun J.;  Xiao F.
Favorite | View/Download:7/0 | TC[WOS]:6 TC[Scopus]:10 | Submit date:2018/12/27
Antagonist peptide  Neurite regeneration  Nogo-66 receptor  Phage display  
Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
MOLECULAR BIOSYSTEMS, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:11/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2020/07/30
Recombinant Nogo-66 via soluble expression with SUMO fusion in Escherichia coli inhibits neurite outgrowth in vitro Journal article
Applied Microbiology and Biotechnology, 2015,Volume: 99,Issue: 14,Page: 5997-6007
Authors:  Dai X.;  Sun Z.;  Liang R.;  Li Y.;  Luo H.;  Huang Y.;  Chen M.;  Su Z.;  Xiao F.
Favorite | View/Download:10/0 | TC[WOS]:4 TC[Scopus]:5 | Submit date:2018/12/27
Bioassay  Expression  Nogo-66  Purification  Small ubiquitin-related modifier  
Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer Journal article
ACS Chemical Neuroscience, 2015,Volume: 6,Issue: 9,Page: 1536-1545
Authors:  Hu S.;  Cui W.;  Mak S.;  Xu D.;  Hu Y.;  Tang J.;  Choi C.;  Lee M.;  Pang Y.;  Han Y.
Favorite | View/Download:11/0 | TC[WOS]:16 TC[Scopus]:18 | Submit date:2018/11/06
Alpha7-nicotinic Acetylcholine Receptor  Alzheimer's Disease  Bis(Propyl)-cognitin  Extracellular Signal-regulated Kinase  Neurite Outgrowth  Neuroprotection