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N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF Journal article
MOLECULAR NEUROBIOLOGY, 2018,Volume: 55,Issue: 3,Page: 2258-2267
Authors:  Luo, Dan;  Zhao, Jia;  Cheng, Yuanyuan;  Lee, Simon Ming-Yuen;  Rong, Jianhui
Favorite | View/Download:14/0 | TC[WOS]:8 TC[Scopus]:15 | Submit date:2018/10/31
Parkinson's disease  Neuroprotection  N-propargyl caffeamide (PACA)  NGF/TrkApathway  PI3K/Akt  ERK1/2  
Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B Journal article
NEUROPHARMACOLOGY, 2017,Volume: 126,Page: 12-24
Authors:  Guo, Baojian;  Hu, Shengquan;  Zheng, Chengyou;  Wang, Hongyu;  Luo, Fangcheng;  Li, Haitao;  Cui, Wei;  Yang, Xifei;  Cui, Guozhen;  Mak, Shinghung;  Choi, Tony Chung-Lit;  Ma, Edmond Dik-Lung;  Wang, Yuqiang;  Lee, Simon Ming Yuen;  Zhang, Zaijun;  Han, Yifan
View | Adobe PDF | Favorite | View/Download:521/10 | TC[WOS]:7 TC[Scopus]:12 | Submit date:2018/10/31
Parkinson's disease  SU4312  Neuroprotection  Myocyte enhancer factor 2D  Monoamine oxidase-B  
ROCK in CNS: Different Roles of Isoforms and Therapeutic Target for Neurodegenerative Disorders Journal article
CURRENT DRUG TARGETS, 2017,Volume: 18,Issue: 4,Page: 455-462
Authors:  Chong, Cheong-Meng;  Ai, Nana;  Lee, Simon Ming-Yuen
Favorite | View/Download:35/0 | TC[WOS]:14 TC[Scopus]:17 | Submit date:2018/10/30
Axonal Regeneration  Central Nervous System  Fasudil  Isoforms  Limk  Neurodegenerative Diseases  Rock  
Discovery of a novel ROCK2 inhibitor with anti-migration effects: Via docking and high-content drug screening Journal article
Molecular BioSystems, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:13/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2018/11/06
Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening Journal article
MOLECULAR BIOSYSTEMS, 2016,Volume: 12,Issue: 9,Page: 2713-2721
Authors:  Cheong-Meng Chong;  Man-Teng Kou;  Peichen Pan;  Hefeng Zhou;  Nana Ai;  Chuwen Li;  Hai-Jing Zhong;  Chung-Hang Leung;  Tingjun Hou;  Simon Ming-Yuen Lee
Favorite | View/Download:11/0 | TC[WOS]:4 TC[Scopus]:4 | Submit date:2020/07/30
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR Journal article
BRAIN RESEARCH, 2011,Volume: 1401,Issue: 15,Page: 10-17
Authors:  Cui, Wei;  Cui, Guo-Zhen;  Li, Wenming;  Zhang, Zaijun;  Hu, Shengquan;  Mak, Shinghung;  Zhang, Huan;  Carlier, Paul R.;  Choi, Chung-lit;  Wong, Yi-Tao;  Lee, Simon Ming-Yuen;  Han, Yifan
Favorite | View/Download:11/0 | TC[WOS]:19 TC[Scopus]:21 | Submit date:2018/11/01
Bis(12)-hupyridone  Huperzine a  Neural Stem Cell  Neurodegenerative Disorder  Differentiation  Alpha 7nachr