UM
Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells
Mei Y.2; Wang Y.2; Xu L.2
2007-05-15
Source PublicationImmunology Letters
ISSN01652478
Volume110Issue:1Pages:29-35
AbstractCell vaccination via immunization with attenuated pathogenic cells is an effective preventive method that has been successfully applied in several animal models of inflammatory or autoimmune diseases. Concanavalin A (Con A)-induced hepatitis (CIH) is a commonly used experimental model to study immune-mediated liver injury. Multiple cell types including T lymphocytes, macrophages and neutrophils have been found to be involved in the pathogenesis of CIH. In this study, we used attenuated spleen lymphocytes or peripheral blood lymphocytes as vaccines to investigate whether they could induce protective immune responses to prevent mice from developing CIH. We found that mice receiving such vaccination before CIH induction developed much milder diseases, exhibited a lower level of alanine aminotransferase (ALT) released into their plasma and had less inflammatory lesions in their livers. Such CIH-suppression is dose- and frequency-dependent. The suppressive effect was associated with inhibition of several major inflammatory mediators, pro-inflammatory cytokines and chemokines. © 2007 Elsevier B.V. All rights reserved.
KeywordCell vaccination Con A-induced hepatitis Immune-mediated liver injury
DOI10.1016/j.imlet.2007.02.008
URLView the original
Language英語
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Institute for Biological Sciences Chinese Academy of Sciences
2.Shanghai Jiao Tong University School of Medicine
Recommended Citation
GB/T 7714
Mei Y.,Wang Y.,Xu L.. Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells[J]. Immunology Letters,2007,110(1):29-35.
APA Mei Y.,Wang Y.,&Xu L..(2007).Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells.Immunology Letters,110(1),29-35.
MLA Mei Y.,et al."Suppression of immune-mediated liver injury after vaccination with attenuated pathogenic cells".Immunology Letters 110.1(2007):29-35.
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