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Comparative proteomic analysis Of indioside d-triggered cell death in HeLa cells
Wong C.C.1; Wang Y.2; Cheng K.-W.1; Chiu J.-F.2; He Q.-Y.3; Chen F.1
2008-05-01
Source PublicationJournal of Proteome Research
ISSN15353893
Volume7Issue:5Pages:2050-2058
Abstract

Medicinal plants represent a rich source of cancer drug leads. Indioside D, a furostanol glycoside isolated from Solanum mammosum, was found to possess antiproliferative activity toward a panel of human cancer cell lines. Proteomic analysis of indioside D-treated HeLa cells revealed profound protein changes related to energy production and oxidative stress, suggesting that mitochondria dysfunction plays a role in indioside D-induced apoptosis. Indioside D caused a rapid dissipation of mitochondrial transmembrane potential (Δψ ) and the generation of reactive oxygen species (ROS), leading to the activation of caspase-dependent apoptotic cell death. The Fas death receptor pathway was also activated following indioside D treatment, and triggered the activation of caspase-8 and cleavage of Bid, which also acted through the mitochondrial apoptosis pathway. These results suggest that indioside D induced apoptosis in HeLa cells via both intrinsic and extrinsic cell death pathways. © 2008 American Chemical Society.

KeywordApoptosis Death Receptors Indioside d Mitochondria Oxidative Stress
DOI10.1021/pr800019k
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods
WOS IDWOS:000255520200025
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被引频次[WOS]:8   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorHe Q.-Y.; Chen F.
Affiliation1.School of Biological Sciences, The University of Hong Kong.
2.Department of Anatomy, The University of Hong Kong.
3.Institute of Life and Health Engineering, Jinan University.
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Wong C.C.,Wang Y.,Cheng K.-W.,et al. Comparative proteomic analysis Of indioside d-triggered cell death in HeLa cells[J]. Journal of Proteome Research,2008,7(5):2050-2058.
APA Wong C.C.,Wang Y.,Cheng K.-W.,Chiu J.-F.,He Q.-Y.,&Chen F..(2008).Comparative proteomic analysis Of indioside d-triggered cell death in HeLa cells.Journal of Proteome Research,7(5),2050-2058.
MLA Wong C.C.,et al."Comparative proteomic analysis Of indioside d-triggered cell death in HeLa cells".Journal of Proteome Research 7.5(2008):2050-2058.
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