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Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals
Wang Y.; Zhou L.M.; Gong J.L.; Zhou M.K.; Shen F.W.; Zheng X.H.; Zhang W.; Zhuang M.H.; Lu W.; Zhong P.; Pan Q.C.; Kang L.Y.
2007-09-01
Source PublicationXi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
ISSN10078738
Volume23Issue:9Pages:816-818
AbstractAIM: To determine the frequency of the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes from the peripheral blood in the Chinese healthy individuals and provide some useful evidence for clinical research of correlative diseases. METHODS: From the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes of peripheral blood in 312 Chinese healthy male and female individuals aged from 8 to 60(five age groups were collected) The expression of transcription factor Foxp3 was detected by triplex immuno fluorescence and the frequency of CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes was determined by flow cytometry. RESULTS: The frequency of CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes in Chinese healthy individuals was (6.55+/-0.11)%, and the frequency differed among age groups(P=0.015) and sex groups(P<0.05). CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes specifically express transcription factor Foxp3. CONCLUSION: The frequency of the CD4(+)CD25(nt/hi)CD127(lo) regulatory T lymphocytes from the peripheral blood in the Chinese healthy individuals has been preliminarily determined which lays the foundation for further clinical research of regulatory T lymphocytes. As a specific cell surface marker, CD25(nt/hi)CD127(lo) can helpful obtain pure CD4(+)CD25(+) regulatory T lymphocytes and suppress the interference of other cells during cell separation.
URLView the original
Language英語
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
AffiliationShanghai Municipal Center for AIDS Research Director
Recommended Citation
GB/T 7714
Wang Y.,Zhou L.M.,Gong J.L.,et al. Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals[J]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,2007,23(9):816-818.
APA Wang Y..,Zhou L.M..,Gong J.L..,Zhou M.K..,Shen F.W..,...&Kang L.Y..(2007).Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals.Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,23(9),816-818.
MLA Wang Y.,et al."Frequency of the CD4+CD25nt/hiCD127lo regulatory T lymphocytes from the peripheral blood in Chinese healthy individuals".Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 23.9(2007):816-818.
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