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In situ expression of IFN-γ-inducible T cell α chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression
Chu Y.3; Yang X.3; Xu W.3; Wang Y.3; Guo Q.3; Xiong S.3
2007-10-01
Source PublicationCancer Immunology, Immunotherapy
ISSN03407004
Volume56Issue:10Pages:1539-1549
AbstractIncreased evidence indicates that chemokines are involved in tumor growth. ITAC, a key member of chemokines, possesses the ability to recruit T cells and enhance immune responses. Therefore, ITAC might contribute to antitumor immunity. In this study, we evaluated the relationship between the expression of ITAC and human breast cancer advancement. We further investigated whether forced expression of ITAC in tumor sites could mediate enhanced antitumor immunity in a murine breast cancer model. Results showed that ITAC expression level was down-regulated in 31 breast cancer specimens compared to normal mammary tissues, and associated negatively with the stages of breast cancer. Contrarily, forced expression of ITAC in murine 4T1 tumor cells resulted in tumor regression after initial growth upon injection into naïve Balb/c mice. More lymphocytes were recruited to the site of tumor inoculated by 4T1-ITAC and more than 80% of these T cells expressed the ITAC receptor, CXCR3. ITAC-recruited TILs exhibited 4T1-specific proliferation and cytotoxicity, and an increased IFN-γ but decreased IL-4 production. Importantly, forced expression of ITAC in 4T1 tumor nodules inhibited tumor growth. These findings demonstrated that the decreased expression of ITAC is associated with the advancement of breast cancer in patients. Forced expression of ITAC in tumor site not only induces increased T cell-recruitment and elicits a specific antitumor immunity, but also mediates regression of established 4T1 tumors, indicating the potential application of ITAC-expressing tumor cells in cancer immunotherapy and vaccine designing. © 2007 Springer-Verlag.
Keyword4T1 tumor Antitumor immunity Chemokine ITAC Tumor regression
DOI10.1007/s00262-007-0296-1
URLView the original
Language英語
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.E-Institute of Shanghai Universities
2.Fudan University
3.Fudan University Shanghai Medical College
Recommended Citation
GB/T 7714
Chu Y.,Yang X.,Xu W.,et al. In situ expression of IFN-γ-inducible T cell α chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression[J]. Cancer Immunology, Immunotherapy,2007,56(10):1539-1549.
APA Chu Y.,Yang X.,Xu W.,Wang Y.,Guo Q.,&Xiong S..(2007).In situ expression of IFN-γ-inducible T cell α chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression.Cancer Immunology, Immunotherapy,56(10),1539-1549.
MLA Chu Y.,et al."In situ expression of IFN-γ-inducible T cell α chemoattractant in breast cancer mounts an enhanced specific anti-tumor immunity which leads to tumor regression".Cancer Immunology, Immunotherapy 56.10(2007):1539-1549.
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