UM
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders
Shi Z.-C.; Devasagayaraj A.; Gu K.; Jin H.; Marinelli B.; Samala L.; Scott S.; Stouch T.; Tunoori A.; Wang Y.; Zang Y.; Zhang C.; Kimball S.D.; Main A.J.; Sun W.; Yang Q.; Nouraldeen A.; Yu X.-Q.; Buxton E.; Patel S.; Nguyen N.; Swaffield J.; Powell D.R.; Wilson A.; Liu Q.
2008-07-10
Source PublicationJournal of Medicinal Chemistry
ISSN00222623
Volume51Issue:13Pages:3684-3687
AbstractThe discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochemical and cell-based assays, and it selectively reduces serotonin levels in the murine intestine after oral administration without affecting levels in the brain. These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome. © 2008 American Chemical Society.
DOI10.1021/jm800338j
URLView the original
Language英語
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Cited Times [WOS]:43   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationLexicon Pharmaceuticals
Recommended Citation
GB/T 7714
Shi Z.-C.,Devasagayaraj A.,Gu K.,et al. Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders[J]. Journal of Medicinal Chemistry,2008,51(13):3684-3687.
APA Shi Z.-C..,Devasagayaraj A..,Gu K..,Jin H..,Marinelli B..,...&Liu Q..(2008).Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.Journal of Medicinal Chemistry,51(13),3684-3687.
MLA Shi Z.-C.,et al."Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders".Journal of Medicinal Chemistry 51.13(2008):3684-3687.
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