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Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis
Wang Y.; Mei Y.; Feng D.; Xu L.
2008-08-15
Source PublicationJournal of Neuroscience Research
ISSN03604012 10974547
Volume86Issue:11Pages:2441-2449
AbstractTriptolide (TPT), a diterpenoid triepoxide, is the major component isolated from the Chinese herb Tripterygium wilfordii Hook. f. Previous studies have shown that TPT has immunosuppressive properties and is effective in prolonging graft survival and suppressing autoimmune responses. The aim of this study was to investigate the protective effect of TPT in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Treatment of C57BL/6 mice with TPT from the date of EAE induction significantly delayed EAE onset and suppressed disease severity, accompanied with reduced inflammation and demyelination in the central nervous system. TPT treatment lead to a significant inhibition of the mRNA expression of both Th1/Th and Th2 cytokines in spleen mononuclear cells (MNC) as well as in spinal cord tissues. In addition, the expression of Forkhead box p3 (Foxp3) was up-regulated in spleen MNC after TPT treatment. Furthermore, we detected apparent inhibition of nuclear factor-kappa B (NF-κB)-DNA binding activity, increased expression of the inhibitor of nuclear factor-kappa Bα (IκBα) and decreased expression of pIκBα in spleen MNC in TPT-treated EAE mice. Taken together, these findings indicate that TPT has profound immunoregulatory functions and potential protective values for the treatment of autoimmune inflammatory disorders. © 2008 Wiley-Liss, Inc.
KeywordExperimental autoimmune encephalomyelitis Multiple sclerosis NF-κB Triptolide
DOI10.1002/jnr.21683
URLView the original
Language英語
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationShanghai Jiao Tong University School of Medicine
Recommended Citation
GB/T 7714
Wang Y.,Mei Y.,Feng D.,et al. Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis[J]. Journal of Neuroscience Research,2008,86(11):2441-2449.
APA Wang Y.,Mei Y.,Feng D.,&Xu L..(2008).Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.Journal of Neuroscience Research,86(11),2441-2449.
MLA Wang Y.,et al."Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis".Journal of Neuroscience Research 86.11(2008):2441-2449.
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